About 5-hydroxytryptamine receptor 3A
5-hydroxytryptamine receptor 3A (HTR3A) is a protein
from Homo sapiens identified by UniProt accession
P46098, 478 residues long.
MolForge cross-references it against 0 known binders and
402 disease associations.
Target properties
| Protein name | 5-hydroxytryptamine receptor 3A |
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| UniProt accession | P46098 |
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| Gene | HTR3A |
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| Organism | Homo sapiens |
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| Length | 478 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (402)
Diseases linked to this target (Open Targets).
- Chemotherapy-induced nausea and vomiting · score 0.61
- post operative nausea and vomiting · score 0.61
- Nausea · score 0.60
- Nausea and vomiting · score 0.60
- cancer · score 0.60
- Vomiting · score 0.60
- schizophrenia · score 0.60
- major depressive disorder · score 0.59
- irritable bowel syndrome · score 0.59
- pain · score 0.58
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P46098-F1 | alphafold | PREDICTED | 82.62 | — |
Amino-acid sequence (478 residues)
MLLWVQQALL ALLLPTLLAQ GEARRSRNTT RPALLRLSDY LLTNYRKGVR PVRDWRKPTT VSIDVIVYAI LNVDEKNQVL TTYIWYRQYW TDEFLQWNPE DFDNITKLSI PTDSIWVPDI LINEFVDVGK SPNIPYVYIR HQGEVQNYKP LQVVTACSLD IYNFPFDVQN CSLTFTSWLH TIQDINISLW RLPEKVKSDR SVFMNQGEWE LLGVLPYFRE FSMESSNYYA EMKFYVVIRR RPLFYVVSLL LPSIFLMVMD IVGFYLPPNS GERVSFKITL LLGYSVFLII VSDTLPATAI GTPLIGVYFV VCMALLVISL AETIFIVRLV HKQDLQQPVP AWLRHLVLER IAWLLCLREQ STSQRPPATS QATKTDDCSA MGNHCSHMGG PQDFEKSPRD RCSPPPPPRE ASLAVCGLLQ ELSSIRQFLE KRDEIREVAR DWLRVGSVLD KLLFHIYLLA VLAYSITLVM LWSIWQYA
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