Tyramine
Drug profile
Also known as: 2-(p-Hydroxyphenyl)ethylamine, p-Hydroxyphenethylamine, tyramine HCl, tyramine hydrochloride, tyrosamine
Data last refreshed: (DrugCentral release 2024-11-01)
Key facts
Tyramine is a drug catalogued in DrugCentral. DrugCentral lists 7 molecular targets, including Taar1, TAAR1 and Taar1. Recorded indications include Biliary Obstruction with Pruritus, Hypercholesterolemia and Hyperlipidemia.
- Molecular targets: Taar1, TAAR1, Taar1 and TyR1 (7 listed in DrugCentral).
- Indications: Biliary Obstruction with Pruritus, Hypercholesterolemia and Hyperlipidemia.
- Molecular formula: C8H11NO; molecular weight 137.18 g/mol.
Indications & contraindications
Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).
Indications (3)
- Biliary Obstruction with Pruritus
- Hypercholesterolemia
- Hyperlipidemia
Off-label uses (2)
- Chronic diarrhea
- Poisoning by digitalis glycoside
Contraindications (8)
- Blood coagulation disorder
- Calculus in biliary tract
- Classical phenylketonuria
- Complete Biliary Obstruction
- Constipation
- Hemorrhoids
- Hypovolemia
- Kidney disease
Mechanism & targets
Molecular targets (7)
| Target | Gene | Action | Activity |
|---|---|---|---|
| Trace amine-associated receptor 1 | Taar1 | agonist | EC50 7.20 |
| Trace amine-associated receptor 1 | TAAR1 | agonist | EC50 7.16 |
| Trace amine-associated receptor 1 | Taar1 | agonist | EC50 7.10 |
| TyR1 | — | unknown | EC50 6.43 |
| Serotonin (5-HT) receptor | Htr2c|Htr2a|Htr1a|Htr1b|Htr1d|Htr1f|Htr2b|Htr6|Htr7|Htr5a|Htr5b|Htr3a|Htr4|Htr3b | unknown | Kd 5.07 |
| 5-hydroxytryptamine receptor 3A | HTR3A | unknown | EC50 4.59 |
| Beta-secretase 1 | BACE1 | unknown | Kd 2.70 |
Chemical structure
Full physicochemical, ADMET and 3D-structure analysis of Tyramine is on its molecule page.
| Molecular formula | C8H11NO |
|---|---|
| Molecular weight | 137.18 g/mol |
| CAS number | — |
| InChIKey | DZGWFCGJZKJUFP-UHFFFAOYSA-N |
| PubChem CID | 5610 |
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
What is Tyramine used for?
DrugCentral lists the following indications for Tyramine: Biliary Obstruction with Pruritus, Hypercholesterolemia and Hyperlipidemia.
How does Tyramine work?
Its molecular targets in DrugCentral include Taar1 (agonist), TAAR1 (agonist), Taar1 (agonist) and TyR1.
What is the chemical formula of Tyramine?
Tyramine has the molecular formula C8H11NO and a molecular weight of 137.18 g/mol.
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Sources
- DrugCentral drug card 2784 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
- ChEMBL CHEMBL11608 — compound record and bioactivity
- PubChem CID 5610 — chemical identifiers
- DrugBank DB08841 — drug record
- FDA UNII X8ZC7V0OX3 — substance identity
- UniProt Q96RJ0 (TAAR1) — target protein
- UniProt P46098 (HTR3A) — target protein
- UniProt P56817 (BACE1) — target protein
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.