Trace amine-associated receptor 1 (TAAR1)
Homo sapiens — UniProt Q96RJ0
Data last refreshed: (UniProt release unknown)
Key facts
Trace amine-associated receptor 1 (TAAR1) is a protein from Homo sapiens identified by UniProt accession Q96RJ0, 339 residues long. MolForge cross-references it against 13 known binders and 230 disease associations.
- UniProt accession: Q96RJ0; gene symbol TAAR1.
- Organism: Homo sapiens.
- Length: 339 amino acids.
- Approved drugs acting on it (DrugCentral): Tyramine, Amfetamine, Methamphetamine, Octopamine and Hydroxyamfetamine and others.
- Top disease associations (Open Targets): schizophrenia, glioblastoma multiforme and lung adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Trace amine-associated receptor 1 |
|---|---|
| UniProt accession | Q96RJ0 |
| Gene | TAAR1 |
| Organism | Homo sapiens |
| Length | 339 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (6)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (230)
Diseases linked to this target (Open Targets).
- schizophrenia · score 0.41
- glioblastoma multiforme · score 0.24
- lung adenocarcinoma · score 0.19
- cutaneous melanoma · score 0.17
- endometrial cancer · score 0.16
- esophageal cancer · score 0.13
- squamous cell lung carcinoma · score 0.12
- neoplasm · score 0.11
- breast adenocarcinoma · score 0.10
- cancer · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q96RJ0-F1 | alphafold | PREDICTED | 90.08 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q96RJ0.
Amino-acid sequence (339 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target TAAR1?
DrugCentral lists 6 approved drugs whose mechanism of action is TAAR1: Tyramine, Amfetamine, Methamphetamine, Octopamine, Hydroxyamfetamine and Levmetamfetamine.
Which diseases are associated with TAAR1?
The strongest Open Targets associations for TAAR1 are schizophrenia, glioblastoma multiforme, lung adenocarcinoma, cutaneous melanoma and endometrial cancer.
How long is the TAAR1 protein?
The Homo sapiens TAAR1 protein (UniProt Q96RJ0) is 339 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q96RJ0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q96RJ0 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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