About Beta-secretase 1
Beta-secretase 1 (BACE1) is a protein
from Homo sapiens identified by UniProt accession
P56817, 501 residues long.
MolForge cross-references it against 0 known binders and
340 disease associations.
Target properties
| Protein name | Beta-secretase 1 |
|---|
| UniProt accession | P56817 |
|---|
| Gene | BACE1 |
|---|
| Organism | Homo sapiens |
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| Length | 501 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Approved drugs hitting this target (10)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (340)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.43
- Alzheimer disease · score 0.33
- neurodegenerative disease · score 0.24
- neoplasm · score 0.10
- pulse pressure measurement · score 0.09
- insulin resistance · score 0.09
- high density lipoprotein cholesterol measurement · score 0.09
- diastolic blood pressure · score 0.08
- systolic blood pressure · score 0.08
- glioblastoma multiforme · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P56817-F1 | alphafold | PREDICTED | 87.48 | — |
Amino-acid sequence (501 residues)
MAQALPWLLL WMGAGVLPAH GTQHGIRLPL RSGLGGAPLG LRLPRETDEE PEEPGRRGSF VEMVDNLRGK SGQGYYVEMT VGSPPQTLNI LVDTGSSNFA VGAAPHPFLH RYYQRQLSST YRDLRKGVYV PYTQGKWEGE LGTDLVSIPH GPNVTVRANI AAITESDKFF INGSNWEGIL GLAYAEIARP DDSLEPFFDS LVKQTHVPNL FSLQLCGAGF PLNQSEVLAS VGGSMIIGGI DHSLYTGSLW YTPIRREWYY EVIIVRVEIN GQDLKMDCKE YNYDKSIVDS GTTNLRLPKK VFEAAVKSIK AASSTEKFPD GFWLGEQLVC WQAGTTPWNI FPVISLYLMG EVTNQSFRIT ILPQQYLRPV EDVATSQDDC YKFAISQSST GTVMGAVIME GFYVVFDRAR KRIGFAVSAC HVHDEFRTAA VEGPFVTLDM EDCGYNIPQT DESTLMTIAY VMAAICALFM LPLCLMVCQW RCLRCLRQQH DDFADDISLL K
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