Levomepromazine

NERVOUS SYSTEM

Key facts

Levomepromazine is an ofm drug catalogued in DrugCentral. DrugCentral lists 2 molecular targets, including HRH1 and PDR5.

• Approval status: ofm.
• Molecular targets: HRH1 and PDR5 (2 listed in DrugCentral).
• ATC code: N05AA02 (Phenothiazines with aliphatic side-chain).
• Molecular formula: C19H24N2OS; molecular weight 328.47 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Contraindications (39)

• Acute disease of cardiovascular system
• Alcoholism
• Anemia
• Angina pectoris
• At risk for aspiration
• Benign prostatic hyperplasia
• Bradycardia
• Breastfeeding (mother)
• Carcinoma of female breast
• Chronic disease of respiratory system
• Chronic heart failure
• Coma
• Conduction disorder of the heart
• Congenital long QT syndrome
• Disease of liver
• Epilepsy
• Extrapyramidal disease
• Glaucoma
• Hyperglycemia
• Hyperprolactinemia
• Leukopenia
• Metabolic syndrome X
• Myocardial infarction
• Myocardial ischemia
• Neuroleptic malignant syndrome
• Neutropenic disorder
• Obesity
• Organophosphate poisoning
• Orthostatic hypotension
• Parkinsonism
• + 9 more

Mechanism & targets

Molecular targets (2)

Target	Gene	Action	Activity
Histamine H1 receptor	HRH1	unknown	Ki 9.24
Pleiotropic ABC efflux transporter of multiple drugs	PDR5	unknown	IC50 5.02

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
—	FDA	—	IMMUNEX

ATC classification

ATC code	Therapeutic hierarchy
N05AA02	NERVOUS SYSTEM › PSYCHOLEPTICS › ANTIPSYCHOTICS › Phenothiazines with aliphatic side-chain

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Suicide attempt	417.6
Intentional overdose	374.8
Drug interaction	361.6
Toxicity to various agents	357.4
Drug abuse	342.1
Neuroleptic malignant syndrome	323.2
Somnolence	299.9
Intentional self-injury	285.8
Extrapyramidal disorder	266.9
Altered state of consciousness	264.4
Electrocardiogram QT prolonged	250.2
Suicidal ideation	177.7

Chemical structure

• Molecular formula: C₁₉H₂₄N₂OS
• Molecular weight: 328.47 g/mol
• CAS number: 60-99-1
• InChIKey: VRQVVMDWGGWHTJ-CQSZACIVSA-N
• PubChem CID: 72287

COC1=CC2=C(SC3=CC=CC=C3N2C[C@H](C)CN(C)C)C=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Levomepromazine work?

Its molecular targets in DrugCentral include HRH1 and PDR5.

What is the chemical formula of Levomepromazine?

Levomepromazine has the molecular formula C19H24N2OS and a molecular weight of 328.47 g/mol.

Sources

• DrugCentral drug card 1752 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1725730 — compound record and bioactivity
• PubChem CID 72287 — chemical identifiers
• DrugBank DB01403 — drug record
• FDA UNII 9G0LAW7ATQ — substance identity
• DailyMed: FDA labels for Levomepromazine — current prescribing information (label search)
• UniProt P35367 (HRH1) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.