5-hydroxytryptamine receptor 7 (HTR7)

About 5-hydroxytryptamine receptor 7

5-hydroxytryptamine receptor 7 (HTR7) is a protein from Homo sapiens identified by UniProt accession P34969, 479 residues long. MolForge cross-references it against 0 known binders and 127 disease associations.

Target properties

Protein name	5-hydroxytryptamine receptor 7
UniProt accession	P34969
Gene	HTR7
Organism	Homo sapiens
Length	479 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (127)

Diseases linked to this target (Open Targets).

schizophrenia · score 0.59
schizoaffective disorder · score 0.50
post operative nausea and vomiting · score 0.47
depressive disorder · score 0.43
unipolar depression · score 0.37
psychosis · score 0.37
Nausea and vomiting · score 0.37
obesity · score 0.37
movement disorder · score 0.37
mental or behavioural disorder · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P34969-F1	alphafold	PREDICTED	73.29	—

Amino-acid sequence (479 residues)

MMDVNSSGRP DLYGHLRSFL LPEVGRGLPD LSPDGGADPV AGSWAPHLLS EVTASPAPTW DAPPDNASGC GEQINYGRVE KVVIGSILTL ITLLTIAGNC LVVISVCFVK KLRQPSNYLI VSLALADLSV AVAVMPFVSV TDLIGGKWIF GHFFCNVFIA MDVMCCTASI MTLCVISIDR YLGITRPLTY PVRQNGKCMA KMILSVWLLS ASITLPPLFG WAQNVNDDKV CLISQDFGYT IYSTAVAFYI PMSVMLFMYY QIYKAARKSA AKHKFPGFPR VEPDSVIALN GIVKLQKEVE ECANLSRLLK HERKNISIFK REQKAATTLG IIVGAFTVCW LPFFLLSTAR PFICGTSCSC IPLWVERTFL WLGYANSLIN PFIYAFFNRD LRTTYRSLLQ CQYRNINRKL SAAGMHEALK LAERPERPEF VLRACTRRVL LRPEKRPPVS VWVLQSPDHH NWLADKMLTT VEKKVMIHD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards