Cisapride

ALIMENTARY TRACT AND METABOLISM

Key facts

Cisapride is an ofm drug catalogued in DrugCentral. It was first approved by the FDA in 1993. DrugCentral lists 35 molecular targets, including HTR2A, Htr2c|Htr2a|Htr2b and KCNH2. Recorded indications include Gastroesophageal reflux disease.

• Approval status: ofm (first approved 1993 by the FDA).
• Molecular targets: HTR2A, Htr2c|Htr2a|Htr2b, KCNH2 and HTR2A (35 listed in DrugCentral).
• Indications: Gastroesophageal reflux disease.
• ATC code: A03FA02 (Propulsives).
• Molecular formula: C23H29ClFN3O4; molecular weight 465.95 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Gastroesophageal reflux disease

Off-label uses (1)

• Gastroparesis

Contraindications (19)

• Angina pectoris
• Bradycardia
• Chronic heart failure
• Congenital long QT syndrome
• Disease of liver
• Disorder of electrolytes
• Epilepsy
• Gastrointestinal hemorrhage
• Hypocalcemia
• Hypokalemia
• Hypomagnesemia
• Hypophosphatemia
• Kidney disease
• Mechanical ileus
• Myocardial ischemia
• Prolonged QT interval
• Respiratory insufficiency
• Severe dehydration
• Ventricular arrhythmia

Mechanism & targets

Molecular targets (35)

Target	Gene	Action	Activity
5-hydroxytryptamine receptor 2A	HTR2A	unknown	Ki 8.96
Serotonin 2 (5-HT2) receptor	Htr2c|Htr2a|Htr2b	unknown	Ki 8.21
Potassium voltage-gated channel subfamily H member 2	KCNH2	unknown	IC50 8.19
5-hydroxytryptamine receptor 2A	HTR2A	unknown	Ki 8.14
Alpha-1B adrenergic receptor	Adra1b	unknown	Ki 8.06
5-hydroxytryptamine receptor 4	Htr4	agonist	Ki 8.00
5-hydroxytryptamine receptor 4	HTR4	unknown	Ki 7.84
5-hydroxytryptamine receptor 4	HTR4	agonist	Ki 7.54
Alpha-1A adrenergic receptor	Adra1a	unknown	Ki 7.52
Alpha-2A adrenergic receptor	Adra2a	unknown	Ki 7.52
5-hydroxytryptamine receptor 4	Htr4	agonist	Ki 7.50
Alpha-1D adrenergic receptor	ADRA1D	unknown	Ki 7.31
D(3) dopamine receptor	DRD3	unknown	Ki 7.31
Cytochrome P450 2D6	CYP2D6	unknown	IC50 7.16
5-hydroxytryptamine receptor 2B	HTR2B	unknown	Ki 7.15
Serotonin 3 (5-HT3) receptor	Htr3a|Htr3b	unknown	Ki 7.02
Membrane-associated progesterone receptor component 1	Pgrmc1	unknown	Ki 6.96
Alpha-2C adrenergic receptor	ADRA2C	unknown	Ki 6.95
Serotonin 3 (5-HT3) receptor	HTR3E|HTR3B|HTR3A|HTR3D|HTR3C	unknown	Ki 6.82
Sodium-dependent serotonin transporter	SLC6A4	unknown	Ki 6.69

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1993-07-29	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
A03FA02	ALIMENTARY TRACT AND METABOLISM › DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS › PROPULSIVES › Propulsives

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Electrocardiogram QT prolonged	1097.6
Hypoventilation	84.7

Chemical structure

• Molecular formula: C₂₃H₂₉ClFN₃O₄
• Molecular weight: 465.95 g/mol
• CAS number: 81098-60-4
• InChIKey: DCSUBABJRXZOMT-UHFFFAOYSA-N
• PubChem CID: 6917698

COC1CN(CCCOC2=CC=C(F)C=C2)CCC1NC(=O)C1=C(OC)C=C(N)C(Cl)=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Cisapride used for?

DrugCentral lists the following indications for Cisapride: Gastroesophageal reflux disease.

How does Cisapride work?

Its molecular targets in DrugCentral include HTR2A, Htr2c|Htr2a|Htr2b, KCNH2 and HTR2A.

When was Cisapride first approved?

Cisapride was first approved by the FDA in 1993.

What is the chemical formula of Cisapride?

Cisapride has the molecular formula C23H29ClFN3O4 and a molecular weight of 465.95 g/mol.

Sources

• DrugCentral drug card 660 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200788 — compound record and bioactivity
• PubChem CID 6917698 — chemical identifiers
• DrugBank DB00604 — drug record
• FDA UNII UVL329170W — substance identity
• DailyMed: FDA labels for Cisapride — current prescribing information (label search)
• UniProt P28223 (HTR2A) — target protein
• UniProt Q12809 (KCNH2) — target protein
• UniProt Q13639 (HTR4) — target protein
• UniProt P25100 (ADRA1D) — target protein
• UniProt P35462 (DRD3) — target protein
• UniProt P10635 (CYP2D6) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.