5-hydroxytryptamine receptor 4 (HTR4)

About 5-hydroxytryptamine receptor 4

5-hydroxytryptamine receptor 4 (HTR4) is a protein from Homo sapiens identified by UniProt accession Q13639, 388 residues long. MolForge cross-references it against 0 known binders and 236 disease associations.

Target properties

Protein name	5-hydroxytryptamine receptor 4
UniProt accession	Q13639
Gene	HTR4
Organism	Homo sapiens
Length	388 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (7)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (236)

Diseases linked to this target (Open Targets).

schizophrenia · score 0.61
Constipation · score 0.59
post operative nausea and vomiting · score 0.58
migraine disorder · score 0.57
gastroparesis · score 0.56
Chronic constipation · score 0.56
Nausea and vomiting · score 0.54
ileus · score 0.54
Vomiting · score 0.54
irritable bowel syndrome · score 0.54

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13639-F1	alphafold	PREDICTED	80.89	—

Amino-acid sequence (388 residues)

MDKLDANVSS EEGFGSVEKV VLLTFLSTVI LMAILGNLLV MVAVCWDRQL RKIKTNYFIV SLAFADLLVS VLVMPFGAIE LVQDIWIYGE VFCLVRTSLD VLLTTASIFH LCCISLDRYY AICCQPLVYR NKMTPLRIAL MLGGCWVIPT FISFLPIMQG WNNIGIIDLI EKRKFNQNSN STYCVFMVNK PYAITCSVVA FYIPFLLMVL AYYRIYVTAK EHAHQIQMLQ RAGASSESRP QSADQHSTHR MRTETKAAKT LCIIMGCFCL CWAPFFVTNI VDPFIDYTVP GQVWTAFLWL GYINSGLNPF LYAFLNKSFR RAFLIILCCD DERYRRPSIL GQTVPCSTTT INGSTHVLRD AVECGGQWES QCHPPATSPL VAAQPSDT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards