Podophyllotoxin

DERMATOLOGICALS

Key facts

Podophyllotoxin is an ofp drug catalogued in DrugCentral. It was first approved by the FDA in 1990. DrugCentral lists 11 molecular targets, including NR3C1, TUBB2B and TUBA1A. Recorded indications include Condyloma acuminatum.

• Approval status: ofp (first approved 1990 by the FDA).
• Molecular targets: NR3C1, TUBB2B, TUBA1A and CYP3A4 (11 listed in DrugCentral).
• Indications: Condyloma acuminatum.
• ATC code: D06BB04 (Antivirals).
• Molecular formula: C22H22O8; molecular weight 414.41 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Condyloma acuminatum

Contraindications (1)

• Pregnancy, function

Mechanism & targets

Molecular targets (11)

Target	Gene	Action	Activity
Glucocorticoid receptor	NR3C1	unknown	IC50 7.85
Tubulin	TUBB2B	unknown	IC50 6.34
Tubulin alpha-1A chain	TUBA1A	unknown	IC50 6.34
Cytochrome P450 3A4	CYP3A4	unknown	IC50 6.22
Tubulin	TUBB4A|TUBB|TUBA1B|TUBA4A|TUBB4B|TUBB3|TUBA3C|TUBB2A|TUBB8|TUBA3E|TUBA1A|TUBA1C|TUBB6|TUBB2B|TUBB1	unknown	IC50 6.00
Regulatory protein E2	E2	unknown	Kd 5.98
Tubulin	TUBA1A	unknown	Ki 5.66
Cytochrome P450 2C9	CYP2C9	unknown	IC50 5.40
Cytochrome P450 2C19	CYP2C19	unknown	IC50 5.30
Regulatory protein E2	E2	unknown	Kd 4.70
Human papillomavirus regulatory protein E2	E2	unknown	Kd 4.15

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1990-12-13	FDA	—	ACTAVIS LABS UT INC

ATC classification

ATC code	Therapeutic hierarchy
D06BB04	DERMATOLOGICALS › ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE › CHEMOTHERAPEUTICS FOR TOPICAL USE › Antivirals

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Podophyllotoxin is on its molecule page.

• Molecular formula: C₂₂H₂₂O₈
• Molecular weight: 414.41 g/mol
• CAS number: 518-28-5
• InChIKey: YJGVMLPVUAXIQN-XVVDYKMHSA-N
• PubChem CID: 10607

COC1=CC(=CC(OC)=C1OC)[C@H]1[C@@H]2[C@H](COC2=O)[C@@H](O)C2=CC3=C(OCO3)C=C12

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Podophyllotoxin used for?

DrugCentral lists the following indications for Podophyllotoxin: Condyloma acuminatum.

How does Podophyllotoxin work?

Its molecular targets in DrugCentral include NR3C1, TUBB2B, TUBA1A and CYP3A4.

When was Podophyllotoxin first approved?

Podophyllotoxin was first approved by the FDA in 1990.

What is the chemical formula of Podophyllotoxin?

Podophyllotoxin has the molecular formula C22H22O8 and a molecular weight of 414.41 g/mol.

Sources

• DrugCentral drug card 3481 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL61 — compound record and bioactivity
• PubChem CID 10607 — chemical identifiers
• DrugBank DB01179 — drug record
• FDA UNII L36H50F353 — substance identity
• DailyMed: FDA labels for Podophyllotoxin — current prescribing information (label search)
• UniProt P04150 (NR3C1) — target protein
• UniProt P08684 (CYP3A4) — target protein
• UniProt P11712 (CYP2C9) — target protein
• UniProt P33261 (CYP2C19) — target protein

How this page is built: methodology · editorial policy & corrections.