Noscapine

RESPIRATORY SYSTEM

Key facts

Noscapine is a drug catalogued in DrugCentral. DrugCentral lists 4 molecular targets, including CYP2C19, SLC22A2 and CYP2C9.

• Molecular targets: CYP2C19, SLC22A2, CYP2C9 and SLC47A1 (4 listed in DrugCentral).
• ATC code: R05DA07 (Opium alkaloids and derivatives).
• Molecular formula: C22H23NO7; molecular weight 413.43 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Contraindications (25)

• Acute hepatitis
• Alcoholism
• Angina pectoris
• Chronic heart failure
• Continuous fever
• Cor pulmonale
• Cystic fibrosis
• Diabetes mellitus
• Disease of liver
• Hypertensive disorder
• Hyperthyroidism
• Hypothyroidism
• Multiple organ failure
• Myocardial infarction
• Peptic ulcer
• Pulmonary edema
• Seizure disorder
• Sepsis syndrome
• Severe Hypoxemia
• Shock
• Smokes tobacco daily
• Smoking cessation assistance
• Tachyarrhythmia
• Theophylline Toxicity
• Third trimester pregnancy

Mechanism & targets

Molecular targets (4)

Target	Gene	Action	Activity
Cytochrome P450 2C19	CYP2C19	unknown	IC50 6.40
Solute carrier family 22 member 2	SLC22A2	unknown	IC50 5.59
Cytochrome P450 2C9	CYP2C9	unknown	IC50 5.09
Multidrug and toxin extrusion protein 1	SLC47A1	unknown	IC50 4.46

ATC classification

ATC code	Therapeutic hierarchy
R05DA07	RESPIRATORY SYSTEM › COUGH AND COLD PREPARATIONS › COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS › Opium alkaloids and derivatives

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Toxicity to various agents	574.7
Drug abuse	299.9
Intentional product misuse	118.2
Asphyxia	118.1
Poisoning	104.9

Chemical structure

• Molecular formula: C₂₂H₂₃NO₇
• Molecular weight: 413.43 g/mol
• CAS number: —
• InChIKey: AKNNEGZIBPJZJG-MSOLQXFVSA-N
• PubChem CID: 275196

COC1=CC=C2[C@H](OC(=O)C2=C1OC)[C@@H]1N(C)CCC2=C1C(OC)=C1OCOC1=C2

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Noscapine work?

Its molecular targets in DrugCentral include CYP2C19, SLC22A2, CYP2C9 and SLC47A1.

What is the chemical formula of Noscapine?

Noscapine has the molecular formula C22H23NO7 and a molecular weight of 413.43 g/mol.

Sources

• DrugCentral drug card 1973 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL2106732 — compound record and bioactivity
• PubChem CID 275196 — chemical identifiers
• DrugBank DB06174 — drug record
• FDA UNII 8V32U4AOQU — substance identity
• UniProt P33261 (CYP2C19) — target protein
• UniProt O15244 (SLC22A2) — target protein
• UniProt P11712 (CYP2C9) — target protein
• UniProt Q96FL8 (SLC47A1) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.