About Multidrug and toxin extrusion protein 1
Multidrug and toxin extrusion protein 1 (SLC47A1) is a protein
from Homo sapiens identified by UniProt accession
Q96FL8, 570 residues long.
MolForge cross-references it against 0 known binders and
95 disease associations.
Target properties
| Protein name | Multidrug and toxin extrusion protein 1 |
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| UniProt accession | Q96FL8 |
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| Gene | SLC47A1 |
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| Organism | Homo sapiens |
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| Length | 570 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (95)
Diseases linked to this target (Open Targets).
- creatinine measurement · score 0.66
- neurodegenerative disease · score 0.46
- glomerular filtration rate · score 0.46
- lymphocyte count · score 0.44
- urate measurement · score 0.43
- Red cell distribution width · score 0.42
- lymphocyte percentage of leukocytes · score 0.34
- neutrophil percentage of leukocytes · score 0.32
- brain aneurysm · score 0.28
- mean platelet volume · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96FL8-F1 | alphafold | PREDICTED | 85.79 | — |
Amino-acid sequence (570 residues)
MEAPEEPAPV RGGPEATLEV RGSRCLRLSA FREELRALLV LAGPAFLVQL MVFLISFISS VFCGHLGKLE LDAVTLAIAV INVTGVSVGF GLSSACDTLI SQTYGSQNLK HVGVILQRSA LVLLLCCFPC WALFLNTQHI LLLFRQDPDV SRLTQTYVTI FIPALPATFL YMLQVKYLLN QGIVLPQIVT GVAANLVNAL ANYLFLHQLH LGVIGSALAN LISQYTLALL LFLYILGKKL HQATWGGWSL ECLQDWASFL RLAIPSMLML CMEWWAYEVG SFLSGILGMV ELGAQSIVYE LAIIVYMVPA GFSVAASVRV GNALGAGDME QARKSSTVSL LITVLFAVAF SVLLLSCKDH VGYIFTTDRD IINLVAQVVP IYAVSHLFEA LACTSGGVLR GSGNQKVGAI VNTIGYYVVG LPIGIALMFA TTLGVMGLWS GIIICTVFQA VCFLGFIIQL NWKKACQQAQ VHANLKVNNV PRSGNSALPQ DPLHPGCPEN LEGILTNDVG KTGEPQSDQQ MRQEEPLPEH PQDGAKLSRK QLVLRRGLLL LGVFLILLVG ILVRFYVRIQ
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