About Solute carrier family 22 member 2
Solute carrier family 22 member 2 (SLC22A2) is a protein
from Homo sapiens identified by UniProt accession
O15244, 555 residues long.
MolForge cross-references it against 0 known binders and
141 disease associations.
Target properties
| Protein name | Solute carrier family 22 member 2 |
|---|
| UniProt accession | O15244 |
|---|
| Gene | SLC22A2 |
|---|
| Organism | Homo sapiens |
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| Length | 555 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (141)
Diseases linked to this target (Open Targets).
- creatinine measurement · score 0.71
- lipoprotein A measurement · score 0.67
- glomerular filtration rate · score 0.53
- chronic kidney disease · score 0.46
- blood metabolite measurement · score 0.42
- prostate carcinoma · score 0.42
- nephrolithiasis · score 0.36
- low density lipoprotein cholesterol measurement · score 0.34
- serum metabolite measurement · score 0.33
- type 2 diabetes mellitus · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O15244-F1 | alphafold | PREDICTED | 83.03 | — |
Amino-acid sequence (555 residues)
MPTTVDDVLE HGGEFHFFQK QMFFLLALLS ATFAPIYVGI VFLGFTPDHR CRSPGVAELS LRCGWSPAEE LNYTVPGPGP AGEASPRQCR RYEVDWNQST FDCVDPLASL DTNRSRLPLG PCRDGWVYET PGSSIVTEFN LVCANSWMLD LFQSSVNVGF FIGSMSIGYI ADRFGRKLCL LTTVLINAAA GVLMAISPTY TWMLIFRLIQ GLVSKAGWLI GYILITEFVG RRYRRTVGIF YQVAYTVGLL VLAGVAYALP HWRWLQFTVS LPNFFFLLYY WCIPESPRWL ISQNKNAEAM RIIKHIAKKN GKSLPASLQR LRLEEETGKK LNPSFLDLVR TPQIRKHTMI LMYNWFTSSV LYQGLIMHMG LAGDNIYLDF FYSALVEFPA AFMIILTIDR IGRRYPWAAS NMVAGAACLA SVFIPGDLQW LKIIISCLGR MGITMAYEIV CLVNAELYPT FIRNLGVHIC SSMCDIGGII TPFLVYRLTN IWLELPLMVF GVLGLVAGGL VLLLPETKGK ALPETIEEAE NMQRPRKNKE KMIYLQVQKL DIPLN
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