Flurazepam

Benzodiazepine — NERVOUS SYSTEM

Key facts

Flurazepam is an ofp drug in the Benzodiazepine class catalogued in DrugCentral. It was first approved by the FDA in 1970. DrugCentral lists 2 molecular targets, including GABRA1|GABRG2|GABRB2 and SLC22A2. Recorded indications include Insomnia.

• Approval status: ofp (first approved 1970 by the FDA).
• Drug class: Benzodiazepine.
• Molecular targets: GABRA1|GABRG2|GABRB2 and SLC22A2 (2 listed in DrugCentral).
• Indications: Insomnia.
• ATC code: N05CD01 (Benzodiazepine derivatives).
• Molecular formula: C21H23ClFN3O; molecular weight 387.88 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Insomnia

Contraindications (19)

• Alcohol intoxication
• Behavioral Disorders
• Borderline personality disorder
• Breastfeeding (mother)
• Coma
• Decreased respiratory function
• Depressive disorder
• Disease of liver
• Disorder of lung
• Hypoalbuminemia
• Kidney disease
• Porphyria
• Pregnancy, function
• Psychotic disorder
• Shock
• Sleep apnea
• Sleep automatism
• Substance abuse
• Suicidal thoughts

Mechanism & targets

• Established pharmacologic class: Benzodiazepine

Molecular targets (2)

Target	Gene	Action	Activity
GABA-A receptor alpha-1/beta-2/gamma-2	GABRA1|GABRG2|GABRB2	positive allosteric modulator	IC50 8.10
Solute carrier family 22 member 2	SLC22A2	unknown	IC50 4.22

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1970-04-07	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
N05CD01	NERVOUS SYSTEM › PSYCHOLEPTICS › HYPNOTICS AND SEDATIVES › Benzodiazepine derivatives

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Sopor	929.4
Drug abuse	738.7
Intentional self-injury	476.3
Suicide attempt	314.7
Intentional overdose	285.2
Toxicity to various agents	212.0
Bradyphrenia	179.7
Coma	122.1
Somnolence	84.1
Drug interaction	79.1
Mydriasis	59.5
Hypokinesia	58.6

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Flurazepam is on its molecule page.

• Molecular formula: C₂₁H₂₃ClFN₃O
• Molecular weight: 387.88 g/mol
• CAS number: 17617-23-1
• InChIKey: SAADBVWGJQAEFS-UHFFFAOYSA-N
• PubChem CID: 3393

CCN(CC)CCN1C2=CC=C(Cl)C=C2C(=NCC1=O)C1=C(F)C=CC=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Flurazepam used for?

DrugCentral lists the following indications for Flurazepam: Insomnia.

How does Flurazepam work?

Its molecular targets in DrugCentral include GABRA1|GABRG2|GABRB2 (positive allosteric modulator) and SLC22A2.

When was Flurazepam first approved?

Flurazepam was first approved by the FDA in 1970.

What drug class does Flurazepam belong to?

Flurazepam is in the Benzodiazepine class.

What is the chemical formula of Flurazepam?

Flurazepam has the molecular formula C21H23ClFN3O and a molecular weight of 387.88 g/mol.

Sources

• DrugCentral drug card 1218 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL3989724 — compound record and bioactivity
• PubChem CID 3393 — chemical identifiers
• DrugBank DB00690 — drug record
• FDA UNII IHP475989U — substance identity
• DailyMed: FDA labels for Flurazepam — current prescribing information (label search)
• UniProt O15244 (SLC22A2) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.