Loprazolam

NERVOUS SYSTEM

Key facts

Loprazolam is a drug catalogued in DrugCentral. It was first approved by the YEAR INTRODUCED in 1983. DrugCentral lists 4 molecular targets, including GABRG2|GABRB3|GABRA2, GABRG2|GABRB3|GABRA3 and GABRG2|GABRB3|GABRA5. Recorded indications include Insomnia.

• Molecular targets: GABRG2|GABRB3|GABRA2, GABRG2|GABRB3|GABRA3, GABRG2|GABRB3|GABRA5 and GABRA1|GABRG2|GABRB3 (4 listed in DrugCentral).
• Indications: Insomnia.
• ATC code: N05CD11 (Benzodiazepine derivatives).
• Molecular formula: C23H21ClN6O3; molecular weight 464.91 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Insomnia

Mechanism & targets

Molecular targets (4)

Target	Gene	Action	Activity
GABA-A receptor alpha-2/beta-3/gamma-2	GABRG2|GABRB3|GABRA2	unknown	—
GABA-A receptor alpha-3/beta-3/gamma-2	GABRG2|GABRB3|GABRA3	unknown	—
GABA-A receptor alpha-5/beta-3/gamma-2	GABRG2|GABRB3|GABRA5	unknown	—
GABA-A receptor alpha-1/beta-3/gamma-2	GABRA1|GABRG2|GABRB3	unknown	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1983-01-01	YEAR INTRODUCED	—	—

ATC classification

ATC code	Therapeutic hierarchy
N05CD11	NERVOUS SYSTEM › PSYCHOLEPTICS › HYPNOTICS AND SEDATIVES › Benzodiazepine derivatives

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Coma	288.8
Miosis	110.2
Somnolence	79.7
Toxicity to various agents	69.2
Pyramidal tract syndrome	66.3
Bradypnoea	65.8
Poisoning deliberate	60.8
Hepatocellular injury	59.9
Rhabdomyolysis	52.3
Acute kidney injury	51.7
Bundle branch block right	41.3

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Loprazolam is on its molecule page.

• Molecular formula: C₂₃H₂₁ClN₆O₃
• Molecular weight: 464.91 g/mol
• CAS number: 61197-73-7
• InChIKey: UTEFBSAVJNEPTR-RGEXLXHISA-N
• PubChem CID: 3033860

CN1CCN(CC1)\C=C1/N=C2CN=C(C3=CC(=CC=C3N2C1=O)[N+]([O-])=O)C1=C(Cl)C=CC=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Loprazolam used for?

DrugCentral lists the following indications for Loprazolam: Insomnia.

How does Loprazolam work?

Its molecular targets in DrugCentral include GABRG2|GABRB3|GABRA2, GABRG2|GABRB3|GABRA3, GABRG2|GABRB3|GABRA5 and GABRA1|GABRG2|GABRB3.

When was Loprazolam first approved?

Loprazolam was first approved by the YEAR INTRODUCED in 1983.

What is the chemical formula of Loprazolam?

Loprazolam has the molecular formula C23H21ClN6O3 and a molecular weight of 464.91 g/mol.

Sources

• DrugCentral drug card 1602 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL2107448 — compound record and bioactivity
• PubChem CID 3033860 — chemical identifiers
• DrugBank DB13643 — drug record
• FDA UNII 759N8462G8 — substance identity
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.