Idoxuridine

Nucleoside Analog Antiviral — DERMATOLOGICALS

Key facts

Idoxuridine is an ofm drug in the Nucleoside Analog Antiviral class catalogued in DrugCentral. It was first approved by the FDA in 1963. DrugCentral lists 2 molecular targets, including TK1 and UL23. Recorded indications include Herpes simplex keratitis.

• Approval status: ofm (first approved 1963 by the FDA).
• Drug class: Nucleoside Analog Antiviral.
• Molecular targets: TK1 and UL23 (2 listed in DrugCentral).
• Indications: Herpes simplex keratitis.
• ATC code: D06BB01 (Antivirals).
• Molecular formula: C9H11IN2O5; molecular weight 354.10 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Herpes simplex keratitis

Off-label uses (1)

• Vaccinia keratitis

Mechanism & targets

• Established pharmacologic class: Nucleoside Analog Antiviral

Molecular targets (2)

Target	Gene	Action	Activity
Thymidine kinase, cytosolic	TK1	unknown	Ki 7.05
Thymidine kinase	UL23	unknown	IC50 5.82

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1963-06-11	FDA	—	ALLERGAN

ATC classification

ATC code	Therapeutic hierarchy
D06BB01	DERMATOLOGICALS › ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE › CHEMOTHERAPEUTICS FOR TOPICAL USE › Antivirals
J05AB02	ANTIINFECTIVES FOR SYSTEMIC USE › ANTIVIRALS FOR SYSTEMIC USE › DIRECT ACTING ANTIVIRALS › Nucleosides and nucleotides excl. reverse transcriptase inhibitors
S01AD01	SENSORY ORGANS › OPHTHALMOLOGICALS › ANTIINFECTIVES › Antivirals

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Idoxuridine is on its molecule page.

• Molecular formula: C₉H₁₁IN₂O₅
• Molecular weight: 354.10 g/mol
• CAS number: 54-42-2
• InChIKey: XQFRJNBWHJMXHO-RRKCRQDMSA-N
• PubChem CID: 5905

OC[C@H]1O[C@H](C[C@@H]1O)N1C=C(I)C(=O)NC1=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Idoxuridine used for?

DrugCentral lists the following indications for Idoxuridine: Herpes simplex keratitis.

How does Idoxuridine work?

Its molecular targets in DrugCentral include TK1 and UL23.

When was Idoxuridine first approved?

Idoxuridine was first approved by the FDA in 1963.

What drug class does Idoxuridine belong to?

Idoxuridine is in the Nucleoside Analog Antiviral class.

What is the chemical formula of Idoxuridine?

Idoxuridine has the molecular formula C9H11IN2O5 and a molecular weight of 354.10 g/mol.

Sources

• DrugCentral drug card 1417 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL788 — compound record and bioactivity
• PubChem CID 5905 — chemical identifiers
• DrugBank DB00249 — drug record
• FDA UNII LGP81V5245 — substance identity
• DailyMed: FDA labels for Idoxuridine — current prescribing information (label search)
• UniProt P04183 (TK1) — target protein

How this page is built: methodology · editorial policy & corrections.