Brivudine

ANTIINFECTIVES FOR SYSTEMIC USE

Key facts

Brivudine is a drug catalogued in DrugCentral. DrugCentral lists 4 molecular targets, including TK1, TK and TK.

• Molecular targets: TK1, TK, TK and UL23 (4 listed in DrugCentral).
• ATC code: J05AB15 (Nucleosides and nucleotides excl. reverse transcriptase inhibitors).
• Molecular formula: C11H13BrN2O5; molecular weight 333.14 g/mol.

Mechanism & targets

Molecular targets (4)

Target	Gene	Action	Activity
Thymidine kinase, cytosolic	TK1	unknown	Ki 7.00
Thymidine kinase	TK	unknown	Ki 6.62
Thymidine kinase	TK	unknown	IC50 6.52
Thymidine kinase	UL23	unknown	IC50 4.49

ATC classification

ATC code	Therapeutic hierarchy
J05AB15	ANTIINFECTIVES FOR SYSTEMIC USE › ANTIVIRALS FOR SYSTEMIC USE › DIRECT ACTING ANTIVIRALS › Nucleosides and nucleotides excl. reverse transcriptase inhibitors

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Labelled drug-drug interaction medication error	183.8
Mucosal inflammation	127.2
Drug interaction	105.8
Pancytopenia	80.9
Pharyngeal inflammation	74.4
Oesophagitis	70.8
Rash maculovesicular	60.7

Chemical structure

• Molecular formula: C₁₁H₁₃BrN₂O₅
• Molecular weight: 333.14 g/mol
• CAS number: 69304-47-8
• InChIKey: ODZBBRURCPAEIQ-PIXDULNESA-N
• PubChem CID: 446727

OC[C@H]1O[C@H](C[C@@H]1O)N1C=C(\C=C\Br)C(=O)NC1=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Brivudine work?

Its molecular targets in DrugCentral include TK1, TK, TK and UL23.

What is the chemical formula of Brivudine?

Brivudine has the molecular formula C11H13BrN2O5 and a molecular weight of 333.14 g/mol.

Sources

• DrugCentral drug card 397 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL31634 — compound record and bioactivity
• PubChem CID 446727 — chemical identifiers
• DrugBank DB03312 — drug record
• FDA UNII 2M3055079H — substance identity
• UniProt P04183 (TK1) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.