Penciclovir

Herpesvirus Nucleoside Analog DNA Polymerase Inhibitor — DERMATOLOGICALS

Key facts

Penciclovir is an ofp drug in the Herpesvirus Nucleoside Analog DNA Polymerase Inhibitor class catalogued in DrugCentral. It was first approved by the FDA in 1996. Its mechanism of action is classified as DNA Polymerase Inhibitors. DrugCentral lists 3 molecular targets, including TK, UL23 and DNA polymerase catalytic subunit. Recorded indications include Herpes labialis.

• Approval status: ofp (first approved 1996 by the FDA).
• Drug class: Herpesvirus Nucleoside Analog DNA Polymerase Inhibitor.
• Mechanism of action: DNA Polymerase Inhibitors.
• Molecular targets: TK, UL23 and DNA polymerase catalytic subunit (3 listed in DrugCentral).
• Indications: Herpes labialis.
• ATC code: D06BB06 (Antivirals).
• Molecular formula: C10H15N5O3; molecular weight 253.26 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Herpes labialis

Mechanism & targets

• Mechanism of action (MoA): DNA Polymerase Inhibitors
• Established pharmacologic class: Herpesvirus Nucleoside Analog DNA Polymerase Inhibitor

Molecular targets (3)

Target	Gene	Action	Activity
Thymidine kinase	TK	unknown	IC50 4.96
Thymidine kinase	UL23	unknown	IC50 4.07
DNA polymerase catalytic subunit	—	inhibitor	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1996-09-24	FDA	—	DENCO ASSET

ATC classification

ATC code	Therapeutic hierarchy
D06BB06	DERMATOLOGICALS › ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE › CHEMOTHERAPEUTICS FOR TOPICAL USE › Antivirals
J05AB13	ANTIINFECTIVES FOR SYSTEMIC USE › ANTIVIRALS FOR SYSTEMIC USE › DIRECT ACTING ANTIVIRALS › Nucleosides and nucleotides excl. reverse transcriptase inhibitors

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Penciclovir is on its molecule page.

• Molecular formula: C₁₀H₁₅N₅O₃
• Molecular weight: 253.26 g/mol
• CAS number: 39809-25-1
• InChIKey: JNTOCHDNEULJHD-UHFFFAOYSA-N
• PubChem CID: 135398748

NC1=NC(=O)C2=C(N1)N(CCC(CO)CO)C=N2

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Penciclovir used for?

DrugCentral lists the following indications for Penciclovir: Herpes labialis.

How does Penciclovir work?

Penciclovir is classified as DNA Polymerase Inhibitors; its molecular targets in DrugCentral include TK, UL23 and DNA polymerase catalytic subunit (inhibitor).

When was Penciclovir first approved?

Penciclovir was first approved by the FDA in 1996.

What drug class does Penciclovir belong to?

Penciclovir is in the Herpesvirus Nucleoside Analog DNA Polymerase Inhibitor class.

What is the chemical formula of Penciclovir?

Penciclovir has the molecular formula C10H15N5O3 and a molecular weight of 253.26 g/mol.

Sources

• DrugCentral drug card 2079 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1540 — compound record and bioactivity
• PubChem CID 135398748 — chemical identifiers
• DrugBank DB00299 — drug record
• FDA UNII 359HUE8FJC — substance identity
• DailyMed: FDA labels for Penciclovir — current prescribing information (label search)

How this page is built: methodology · editorial policy & corrections.