Diquafosol

SENSORY ORGANS

Key facts

Diquafosol is a drug catalogued in DrugCentral. It was first approved by the PMDA in 2010. DrugCentral lists 2 molecular targets, including P2RY2 and P2RY4. Recorded indications include Tear film insufficiency.

• Molecular targets: P2RY2 and P2RY4 (2 listed in DrugCentral).
• Indications: Tear film insufficiency.
• ATC code: S01XA33 (Other ophthalmologicals).
• Molecular formula: C18H26N4O23P4; molecular weight 790.31 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Tear film insufficiency

Mechanism & targets

Molecular targets (2)

Target	Gene	Action	Activity
P2Y purinoceptor 2	P2RY2	agonist	EC50 7.47
P2Y purinoceptor 4	P2RY4	agonist	EC50 6.40

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2010-02-09	PMDA	—	Santen Pharmaceutical

ATC classification

ATC code	Therapeutic hierarchy
S01XA33	SENSORY ORGANS › OPHTHALMOLOGICALS › OTHER OPHTHALMOLOGICALS › Other ophthalmologicals

Chemical structure

• Molecular formula: C₁₈H₂₆N₄O₂₃P₄
• Molecular weight: 790.31 g/mol
• CAS number: 59985-21-6
• InChIKey: NMLMACJWHPHKGR-NCOIDOBVSA-N
• PubChem CID: 148197

O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=CC(=O)NC1=O)N1C=CC(=O)NC1=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Diquafosol used for?

DrugCentral lists the following indications for Diquafosol: Tear film insufficiency.

How does Diquafosol work?

Its molecular targets in DrugCentral include P2RY2 (agonist) and P2RY4 (agonist).

When was Diquafosol first approved?

Diquafosol was first approved by the PMDA in 2010.

What is the chemical formula of Diquafosol?

Diquafosol has the molecular formula C18H26N4O23P4 and a molecular weight of 790.31 g/mol.

Sources

• DrugCentral drug card 4900 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1767408 — compound record and bioactivity
• PubChem CID 148197 — chemical identifiers
• DrugBank DB15919 — drug record
• FDA UNII 7828VC80FJ — substance identity
• UniProt P41231 (P2RY2) — target protein
• UniProt P51582 (P2RY4) — target protein

How this page is built: methodology · editorial policy & corrections.