P2Y purinoceptor 2 (P2RY2)

About P2Y purinoceptor 2

P2Y purinoceptor 2 (P2RY2) is a protein from Homo sapiens identified by UniProt accession P41231, 377 residues long. MolForge cross-references it against 0 known binders and 244 disease associations.

Target properties

Protein name	P2Y purinoceptor 2
UniProt accession	P41231
Gene	P2RY2
Organism	Homo sapiens
Length	377 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (4)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (244)

Diseases linked to this target (Open Targets).

dry eye syndrome · score 0.56
basophil count · score 0.53
basophil percentage of leukocytes · score 0.50
monocyte count · score 0.50
platelet component distribution width · score 0.48
blood protein measurement · score 0.47
serum alanine aminotransferase measurement · score 0.46
aspartate aminotransferase measurement · score 0.44
platelet crit · score 0.43
reticulocyte count · score 0.42

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P41231-F1	alphafold	PREDICTED	78.86	—

Amino-acid sequence (377 residues)

MAADLGPWND TINGTWDGDE LGYRCRFNED FKYVLLPVSY GVVCVPGLCL NAVALYIFLC RLKTWNASTT YMFHLAVSDA LYAASLPLLV YYYARGDHWP FSTVLCKLVR FLFYTNLYCS ILFLTCISVH RCLGVLRPLR SLRWGRARYA RRVAGAVWVL VLACQAPVLY FVTTSARGGR VTCHDTSAPE LFSRFVAYSS VMLGLLFAVP FAVILVCYVL MARRLLKPAY GTSGGLPRAK RKSVRTIAVV LAVFALCFLP FHVTRTLYYS FRSLDLSCHT LNAINMAYKV TRPLASANSC LDPVLYFLAG QRLVRFARDA KPPTGPSPAT PARRRLGLRR SDRTDMQRIE DVLGSSEDSR RTESTPAGSE NTKDIRL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards