About Corticosteroid-binding globulin
Corticosteroid-binding globulin (SERPINA6) is a protein
from Homo sapiens identified by UniProt accession
P08185, 405 residues long.
MolForge cross-references it against 0 known binders and
140 disease associations.
Target properties
| Protein name | Corticosteroid-binding globulin |
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| UniProt accession | P08185 |
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| Gene | SERPINA6 |
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| Organism | Homo sapiens |
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| Length | 405 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (140)
Diseases linked to this target (Open Targets).
- corticosteroid-binding globulin deficiency · score 0.64
- cortisol measurement · score 0.36
- serum alpha-1-antitrypsin measurement · score 0.28
- blood protein measurement · score 0.27
- serum alanine aminotransferase measurement · score 0.26
- diffuse plaque measurement · score 0.24
- genetic disorder · score 0.19
- cystic fibrosis · score 0.07
- low density lipoprotein cholesterol measurement · score 0.07
- platelet count · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P08185-F1 | alphafold | PREDICTED | 86.35 | — |
Amino-acid sequence (405 residues)
MPLLLYTCLL WLPTSGLWTV QAMDPNAAYV NMSNHHRGLA SANVDFAFSL YKHLVALSPK KNIFISPVSI SMALAMLSLG TCGHTRAQLL QGLGFNLTER SETEIHQGFQ HLHQLFAKSD TSLEMTMGNA LFLDGSLELL ESFSADIKHY YESEVLAMNF QDWATASRQI NSYVKNKTQG KIVDLFSGLD SPAILVLVNY IFFKGTWTQP FDLASTREEN FYVDETTVVK VPMMLQSSTI SYLHDSELPC QLVQMNYVGN GTVFFILPDK GKMNTVIAAL SRDTINRWSA GLTSSQVDLY IPKVTISGVY DLGDVLEEMG IADLFTNQAN FSRITQDAQL KSSKVVHKAV LQLNEEGVDT AGSTGVTLNL TSKPIILRFN QPFIIMIFDH FTWSSLFLAR VMNPV
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