Estriol

GENITO URINARY SYSTEM AND SEX HORMONES

Key facts

Estriol is a drug catalogued in DrugCentral. DrugCentral lists 10 molecular targets, including ESR1, ESR2 and SHBG.

• Molecular targets: ESR1, ESR2, SHBG and SLC6A4 (10 listed in DrugCentral).
• ATC code: G03CA04 (Natural and semisynthetic estrogens, plain).
• Molecular formula: C18H24O3; molecular weight 288.39 g/mol.

Mechanism & targets

Molecular targets (10)

Target	Gene	Action	Activity
Estrogen receptor	ESR1	agonist	Ki 8.67
Estrogen receptor beta	ESR2	agonist	Ki 8.40
Sex hormone-binding globulin	SHBG	unknown	Kd 6.63
Sodium-dependent serotonin transporter	SLC6A4	unknown	Ki 5.26
Arachidonate 15-lipoxygenase	ALOX15	unknown	IC50 5.06
Corticosteroid-binding globulin	SERPINA6	unknown	Ki 5.00
Glucocorticoid receptor	NR3C1	unknown	Ki 4.75
Alpha-synuclein	SNCA	unknown	IC50 4.70
Olfactory receptor 51E2	OR51E2	unknown	EC50 4.28
Lanosterol 14-alpha demethylase	cyp51	unknown	Kd 4.00

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
—	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
G03CA04	GENITO URINARY SYSTEM AND SEX HORMONES › SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM › ESTROGENS › Natural and semisynthetic estrogens, plain
G03CC06	GENITO URINARY SYSTEM AND SEX HORMONES › SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM › ESTROGENS › Estrogens, combinations with other drugs

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Cardiospasm	831.4
Palmoplantar keratoderma	807.0
Pruritus genital	767.3
Sleep terror	766.1
Atrial tachycardia	719.2
Carotid artery occlusion	708.1
Tension headache	702.0
Anosmia	652.2
Facial pain	624.9
Immunisation	580.7
Pain of skin	559.2
Muscle twitching	545.5

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Estriol is on its molecule page.

• Molecular formula: C₁₈H₂₄O₃
• Molecular weight: 288.39 g/mol
• CAS number: —
• InChIKey: PROQIPRRNZUXQM-ZXXIGWHRSA-N
• PubChem CID: 5756

C[C@]12CC[C@H]3[C@@H](CCC4=C3C=CC(O)=C4)[C@@H]1C[C@@H](O)[C@@H]2O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Estriol work?

Its molecular targets in DrugCentral include ESR1 (agonist), ESR2 (agonist), SHBG and SLC6A4.

What is the chemical formula of Estriol?

Estriol has the molecular formula C18H24O3 and a molecular weight of 288.39 g/mol.

Sources

• DrugCentral drug card 3187 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL193482 — compound record and bioactivity
• PubChem CID 5756 — chemical identifiers
• DrugBank DB04573 — drug record
• FDA UNII FB33469R8E — substance identity
• DailyMed: FDA labels for Estriol — current prescribing information (label search)
• UniProt P03372 (ESR1) — target protein
• UniProt Q92731 (ESR2) — target protein
• UniProt P04278 (SHBG) — target protein
• UniProt P31645 (SLC6A4) — target protein
• UniProt P08185 (SERPINA6) — target protein
• UniProt P04150 (NR3C1) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.