Alpha-synuclein (SNCA)
Homo sapiens — UniProt P37840
Data last refreshed: (UniProt release unknown)
Key facts
Alpha-synuclein (SNCA) is a protein from Homo sapiens identified by UniProt accession P37840, 140 residues long. MolForge cross-references it against 25 known binders and 480 disease associations.
- UniProt accession: P37840; gene symbol SNCA.
- Organism: Homo sapiens.
- Length: 140 amino acids.
- Top disease associations (Open Targets): Hereditary late-onset Parkinson disease, Lewy body dementia and Parkinson disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Alpha-synuclein |
|---|---|
| UniProt accession | P37840 |
| Gene | SNCA |
| Organism | Homo sapiens |
| Length | 140 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (480)
Diseases linked to this target (Open Targets).
- Hereditary late-onset Parkinson disease · score 0.79
- Lewy body dementia · score 0.73
- Parkinson disease · score 0.71
- Young adult-onset Parkinsonism · score 0.70
- neuroticism measurement · score 0.48
- AL amyloidosis · score 0.46
- blood protein measurement · score 0.46
- mean corpuscular volume · score 0.39
- parkinsonian-pyramidal syndrome · score 0.37
- insomnia measurement · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-P37840-F1 | alphafold | PREDICTED | 75.18 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for P37840.
Amino-acid sequence (140 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SNCA?
The strongest Open Targets associations for SNCA are Hereditary late-onset Parkinson disease, Lewy body dementia, Parkinson disease, Young adult-onset Parkinsonism and neuroticism measurement.
How long is the SNCA protein?
The Homo sapiens SNCA protein (UniProt P37840) is 140 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB P37840 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB P37840 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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