Dienestrol
GENITO URINARY SYSTEM AND SEX HORMONES
Also known as: cycladiene, dienesterol, dienoestrol, estrodienol, follidiene, oestrodiene, synestrol
Data last refreshed: (DrugCentral release 2024-11-01)
Key facts
Dienestrol is an ofm drug catalogued in DrugCentral. It was first approved by the FDA in 1947. DrugCentral lists 1 molecular target, including ESR1. Recorded indications include Atrophic vaginitis, Atrophic vulva and Dyspareunia.
- Approval status: ofm (first approved 1947 by the FDA).
- Molecular targets: ESR1 (1 listed in DrugCentral).
- Indications: Atrophic vaginitis, Atrophic vulva and Dyspareunia.
- ATC code: G03CB01 (Synthetic estrogens, plain).
- Molecular formula: C18H18O2; molecular weight 266.34 g/mol.
Indications & contraindications
Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).
Indications (3)
- Atrophic vaginitis
- Atrophic vulva
- Dyspareunia
Contraindications (34)
- Acute Thromboembolic Stroke
- Carcinoma of female breast
- Cardiovascular event risk
- Cerebrovascular accident
- Deep venous thrombosis
- Dementia
- Diabetes mellitus
- Disease of liver
- Disorder of cardiovascular system
- Disorder of coronary artery
- Disorder of gallbladder
- Endometrial carcinoma
- Endometriosis
- Epilepsy
- Estrogen receptor positive tumor
- Hepatic porphyria
- Humoral hypercalcemia of malignancy
- Hypertensive disorder
- Hypertriglyceridemia
- Hypothyroidism
- Intermenstrual bleeding - irregular
- Malignant tumor of ovary
- Mammography abnormal
- Myocardial infarction
- Neoplasm of female genital organ
- Pregnancy, function
- Pulmonary thromboembolism
- Resistance to activated protein C due to Factor V Leiden
- Smokes tobacco daily
- Systemic lupus erythematosus
- + 4 more
Mechanism & targets
Molecular targets (1)
| Target | Gene | Action | Activity |
|---|---|---|---|
| Estrogen receptor | ESR1 | agonist | EC50 4.88 |
Regulatory approvals (1)
| Date | Agency | Marketed as | Applicant | Orphan |
|---|---|---|---|---|
| 1947-01-09 | FDA | — | ORTHO MCNEIL PHARM |
ATC classification
| ATC code | Therapeutic hierarchy |
|---|---|
G03CB01 | GENITO URINARY SYSTEM AND SEX HORMONES › SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM › ESTROGENS › Synthetic estrogens, plain |
G03CC02 | GENITO URINARY SYSTEM AND SEX HORMONES › SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM › ESTROGENS › Estrogens, combinations with other drugs |
Chemical structure
Full physicochemical, ADMET and 3D-structure analysis of Dienestrol is on its molecule page.
| Molecular formula | C18H18O2 |
|---|---|
| Molecular weight | 266.34 g/mol |
| CAS number | 84-17-3 |
| InChIKey | NFDFQCUYFHCNBW-SCGPFSFSSA-N |
| PubChem CID | 667476 |
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
What is Dienestrol used for?
DrugCentral lists the following indications for Dienestrol: Atrophic vaginitis, Atrophic vulva and Dyspareunia.
How does Dienestrol work?
Its molecular targets in DrugCentral include ESR1 (agonist).
When was Dienestrol first approved?
Dienestrol was first approved by the FDA in 1947.
What is the chemical formula of Dienestrol?
Dienestrol has the molecular formula C18H18O2 and a molecular weight of 266.34 g/mol.
Browse: all drugs starting with D · drug guides by category · protein targets A–Z.
Sources
- DrugCentral drug card 870 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
- ChEMBL CHEMBL1018 — compound record and bioactivity
- PubChem CID 667476 — chemical identifiers
- DrugBank DB00890 — drug record
- FDA UNII RRW32X4U1F — substance identity
- DailyMed: FDA labels for Dienestrol — current prescribing information (label search)
- UniProt P03372 (ESR1) — target protein
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.