Hydroxyprogesterone caproate

Progestin — GENITO URINARY SYSTEM AND SEX HORMONES

Key facts

Hydroxyprogesterone caproate is an ofm drug in the Progestin class catalogued in DrugCentral. It was first approved by the FDA in 1975. DrugCentral lists 9 molecular targets, including PGR, SERPINA6 and PGR. Recorded indications include Prevention of Premature Labor.

• Approval status: ofm (first approved 1975 by the FDA).
• Drug class: Progestin.
• Molecular targets: PGR, SERPINA6, PGR and NR3C1 (9 listed in DrugCentral).
• Indications: Prevention of Premature Labor.
• ATC code: G03DA03 (Pregnen (4) derivatives).
• Molecular formula: C27H40O4; molecular weight 428.61 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Prevention of Premature Labor

Off-label uses (1)

• Endometrial carcinoma

Contraindications (21)

• Asthma
• Body fluid retention
• Carcinoma of female breast
• Chronic heart failure
• Deep venous thrombosis
• Depressive disorder
• Diabetes mellitus
• Disease of liver
• Epilepsy
• Hyperglycemia
• Hypertensive disorder
• Impaired glucose tolerance
• Intermenstrual bleeding - irregular
• Jaundice
• Kidney disease
• Migraine
• Mild pre-eclampsia
• Neoplasm of liver
• Predisposition to Thrombosis
• Seizure disorder
• Thromboembolic disorder

Mechanism & targets

• Established pharmacologic class: Progestin

Molecular targets (9)

Target	Gene	Action	Activity
Progesterone receptor	PGR	unknown	Ki 8.81
Corticosteroid-binding globulin	SERPINA6	unknown	Ki 7.74
Progesterone receptor	PGR	agonist	IC50 7.66
Glucocorticoid receptor	NR3C1	unknown	Ki 7.64
Sex hormone-binding globulin	SHBG	unknown	Kd 7.00
Androgen receptor	Ar	unknown	Ki 6.31
Adenosine receptor A3	ADORA3	unknown	Ki 5.57
Mitogen-activated protein kinase 3	MAPK3	unknown	IC50 5.50
Sodium-dependent dopamine transporter	SLC6A3	unknown	Ki 5.26

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1975-10-03	FDA	—	ACTAVIS LABS UT INC

ATC classification

ATC code	Therapeutic hierarchy
G03DA03	GENITO URINARY SYSTEM AND SEX HORMONES › SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM › PROGESTOGENS › Pregnen (4) derivatives
G03FA02	GENITO URINARY SYSTEM AND SEX HORMONES › SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM › PROGESTOGENS AND ESTROGENS IN COMBINATION › Progestogens and estrogens, fixed combinations

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Premature baby	5501.0
Injection site pruritus	2235.0
Injection site pain	1924.6
Preterm premature rupture of membranes	1919.6
Uterine contractions during pregnancy	1379.6
Premature labour	899.3
Injection site mass	880.5
Stillbirth	815.6
Injection site swelling	770.1
Injection site erythema	630.1
Premature delivery	599.9
Cervical incompetence	510.9

Chemical structure

• Molecular formula: C₂₇H₄₀O₄
• Molecular weight: 428.61 g/mol
• CAS number: 630-56-8
• InChIKey: DOMWKUIIPQCAJU-LJHIYBGHSA-N
• PubChem CID: 169870

CCCCCC(=O)O[C@@]1(CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C)C(C)=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Hydroxyprogesterone caproate used for?

DrugCentral lists the following indications for Hydroxyprogesterone caproate: Prevention of Premature Labor.

How does Hydroxyprogesterone caproate work?

Its molecular targets in DrugCentral include PGR, SERPINA6, PGR (agonist) and NR3C1.

When was Hydroxyprogesterone caproate first approved?

Hydroxyprogesterone caproate was first approved by the FDA in 1975.

What drug class does Hydroxyprogesterone caproate belong to?

Hydroxyprogesterone caproate is in the Progestin class.

What is the chemical formula of Hydroxyprogesterone caproate?

Hydroxyprogesterone caproate has the molecular formula C27H40O4 and a molecular weight of 428.61 g/mol.

Sources

• DrugCentral drug card 4189 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200848 — compound record and bioactivity
• PubChem CID 169870 — chemical identifiers
• DrugBank DB06789 — drug record
• FDA UNII 21807M87J2 — substance identity
• DailyMed: FDA labels for Hydroxyprogesterone caproate — current prescribing information (label search)
• UniProt P08185 (SERPINA6) — target protein
• UniProt P06401 (PGR) — target protein
• UniProt P04150 (NR3C1) — target protein
• UniProt P04278 (SHBG) — target protein
• UniProt P0DMS8 (ADORA3) — target protein
• UniProt P27361 (MAPK3) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.