About Adenosine receptor A3
Adenosine receptor A3 (ADORA3) is a protein
from Homo sapiens identified by UniProt accession
P0DMS8, 318 residues long.
MolForge cross-references it against 0 known binders and
283 disease associations.
Target properties
| Protein name | Adenosine receptor A3 |
|---|
| UniProt accession | P0DMS8 |
|---|
| Gene | ADORA3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 318 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (283)
Diseases linked to this target (Open Targets).
- migraine disorder · score 0.61
- asthma · score 0.60
- paroxysmal tachycardia · score 0.59
- Apnea · score 0.58
- pain · score 0.58
- Airway obstruction · score 0.57
- Wolff-Parkinson-White Syndrome · score 0.56
- Headache · score 0.55
- chronic obstructive pulmonary disease · score 0.54
- Acute kidney injury · score 0.51
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P0DMS8-F1 | alphafold | PREDICTED | 91.30 | — |
Amino-acid sequence (318 residues)
MPNNSTALSL ANVTYITMEI FIGLCAIVGN VLVICVVKLN PSLQTTTFYF IVSLALADIA VGVLVMPLAI VVSLGITIHF YSCLFMTCLL LIFTHASIMS LLAIAVDRYL RVKLTVRYKR VTTHRRIWLA LGLCWLVSFL VGLTPMFGWN MKLTSEYHRN VTFLSCQFVS VMRMDYMVYF SFLTWIFIPL VVMCAIYLDI FYIIRNKLSL NLSNSKETGA FYGREFKTAK SLFLVLFLFA LSWLPLSIIN CIIYFNGEVP QLVLYMGILL SHANSMMNPI VYAYKIKKFK ETYLLILKAC VVCHPSDSLD TSIEKNSE
Explore Adenosine receptor A3 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets