Hexachlorophene

Antiseptic — DERMATOLOGICALS

Key facts

Hexachlorophene is an ofp drug in the Antiseptic class catalogued in DrugCentral. It was first approved by the FDA in 1949. DrugCentral lists 38 molecular targets, including MAPK14, ESR2 and MAPK1.

• Approval status: ofp (first approved 1949 by the FDA).
• Drug class: Antiseptic.
• Molecular targets: MAPK14, ESR2, MAPK1 and ADORA3 (38 listed in DrugCentral).
• ATC code: D08AE01 (Phenol and derivatives).
• Molecular formula: C13H6Cl6O2; molecular weight 406.89 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Contraindications (4)

• Breastfeeding (mother)
• Burn injury
• CNS Toxicity
• Denuded skin

Mechanism & targets

• Established pharmacologic class: Antiseptic

Molecular targets (38)

Target	Gene	Action	Activity
Mitogen-activated protein kinase 14	MAPK14	unknown	IC50 7.06
Estrogen receptor beta	ESR2	unknown	IC50 7.01
Mitogen-activated protein kinase 1	MAPK1	unknown	IC50 6.71
Adenosine receptor A3	ADORA3	unknown	Ki 6.44
Prostaglandin G/H synthase 2	PTGS2	unknown	IC50 6.19
Epidermal growth factor receptor	EGFR	unknown	IC50 6.13
Adenosine receptor A2a	ADORA2A	unknown	Ki 6.04
Alpha-2C adrenergic receptor	ADRA2C	unknown	Ki 5.99
Cytochrome P450 2C19	CYP2C19	unknown	IC50 5.91
Cytochrome P450 1A2	CYP1A2	unknown	IC50 5.88
Substance-K receptor	TACR2	unknown	Ki 5.86
Alpha-2A adrenergic receptor	ADRA2A	unknown	Ki 5.69
Estrogen receptor	ESR1	unknown	IC50 5.67
Sodium-dependent serotonin transporter	SLC6A4	unknown	Ki 5.64
5-hydroxytryptamine receptor 2C	HTR2C	unknown	Ki 5.62
Tyrosine-protein kinase Lck	LCK	unknown	IC50 5.61
Mitogen-activated protein kinase 3	MAPK3	unknown	IC50 5.61
Acetylcholinesterase	ACHE	unknown	IC50 5.52
Thromboxane-A synthase	TBXAS1	unknown	IC50 5.51
Androgen receptor	Ar	unknown	Ki 5.48

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1949-04-19	FDA	—	SANOFI AVENTIS US

ATC classification

ATC code	Therapeutic hierarchy
D08AE01	DERMATOLOGICALS › ANTISEPTICS AND DISINFECTANTS › ANTISEPTICS AND DISINFECTANTS › Phenol and derivatives

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Paranasal cyst	198.2
Vascular malformation	196.5
Mastoiditis	168.6

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Hexachlorophene is on its molecule page.

• Molecular formula: C₁₃H₆Cl₆O₂
• Molecular weight: 406.89 g/mol
• CAS number: 70-30-4
• InChIKey: ACGUYXCXAPNIKK-UHFFFAOYSA-N
• PubChem CID: 3598

OC1=C(Cl)C=C(Cl)C(Cl)=C1CC1=C(Cl)C(Cl)=CC(Cl)=C1O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Hexachlorophene work?

Its molecular targets in DrugCentral include MAPK14, ESR2, MAPK1 and ADORA3.

When was Hexachlorophene first approved?

Hexachlorophene was first approved by the FDA in 1949.

What drug class does Hexachlorophene belong to?

Hexachlorophene is in the Antiseptic class.

What is the chemical formula of Hexachlorophene?

Hexachlorophene has the molecular formula C13H6Cl6O2 and a molecular weight of 406.89 g/mol.

Sources

• DrugCentral drug card 1364 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL496 — compound record and bioactivity
• PubChem CID 3598 — chemical identifiers
• DrugBank DB00756 — drug record
• FDA UNII IWW5FV6NK2 — substance identity
• DailyMed: FDA labels for Hexachlorophene — current prescribing information (label search)
• UniProt Q16539 (MAPK14) — target protein
• UniProt Q92731 (ESR2) — target protein
• UniProt P28482 (MAPK1) — target protein
• UniProt P0DMS8 (ADORA3) — target protein
• UniProt P35354 (PTGS2) — target protein
• UniProt P00533 (EGFR) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.