Mitogen-activated protein kinase 14 (MAPK14)

About Mitogen-activated protein kinase 14

Mitogen-activated protein kinase 14 (MAPK14) is a protein from Homo sapiens identified by UniProt accession Q16539, 360 residues long. MolForge cross-references it against 0 known binders and 624 disease associations.

Target properties

Protein name	Mitogen-activated protein kinase 14
UniProt accession	Q16539
Gene	MAPK14
Organism	Homo sapiens
Length	360 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (624)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.46
neuroinflammatory disorder · score 0.46
Alzheimer disease · score 0.33
Parkinson disease · score 0.31
multiple sclerosis · score 0.31
lysosomal storage disease · score 0.30
Facioscapulohumeral dystrophy · score 0.29
acute coronary syndrome · score 0.29
breast adenocarcinoma · score 0.28
endometrial cancer · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q16539-F1	alphafold	PREDICTED	89.77	—

Amino-acid sequence (360 residues)

MSQERPTFYR QELNKTIWEV PERYQNLSPV GSGAYGSVCA AFDTKTGLRV AVKKLSRPFQ SIIHAKRTYR ELRLLKHMKH ENVIGLLDVF TPARSLEEFN DVYLVTHLMG ADLNNIVKCQ KLTDDHVQFL IYQILRGLKY IHSADIIHRD LKPSNLAVNE DCELKILDFG LARHTDDEMT GYVATRWYRA PEIMLNWMHY NQTVDIWSVG CIMAELLTGR TLFPGTDHID QLKLILRLVG TPGAELLKKI SSESARNYIQ SLTQMPKMNF ANVFIGANPL AVDLLEKMLV LDSDKRITAA QALAHAYFAQ YHDPDDEPVA DPYDQSFESR DLLIDEWKSL TYDEVISFVP PPLDQEEMES

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards