Etoricoxib

MUSCULO-SKELETAL SYSTEM

Key facts

Etoricoxib is a drug catalogued in DrugCentral. It was first approved by the YEAR INTRODUCED in 1998. DrugCentral lists 5 molecular targets, including PTGER2, PTGS2 and MAPK14.

• Molecular targets: PTGER2, PTGS2, MAPK14 and PTGS2 (5 listed in DrugCentral).
• ATC code: M01AH05 (Coxibs).
• Molecular formula: C18H15ClN2O2S; molecular weight 358.84 g/mol.

Mechanism & targets

Molecular targets (5)

Target	Gene	Action	Activity
Prostaglandin E2 receptor EP2 subtype	PTGER2	unknown	Ki 7.10
Prostaglandin G/H synthase 2	PTGS2	unknown	IC50 6.64
Mitogen-activated protein kinase 14	MAPK14	unknown	IC50 6.28
Prostaglandin G/H synthase 2	PTGS2	inhibitor	IC50 6.10
Prostaglandin G/H synthase 1	PTGS1	unknown	IC50 4.92

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1998-01-01	YEAR INTRODUCED	—	—

ATC classification

ATC code	Therapeutic hierarchy
M01AH05	MUSCULO-SKELETAL SYSTEM › ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS › ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS › Coxibs

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Axial spondyloarthritis	92.0
Regurgitation	89.2
Drug interaction	86.2
Spinal pain	77.8
Lung adenocarcinoma stage IV	69.4
Hepatitis E antibody positive	61.3
Fixed eruption	59.4
Hepatitis E virus test positive	59.3
Inflammatory marker increased	58.6
Ankylosing spondylitis	55.7
Spinal osteoarthritis	55.5
Pregnancy of partner	53.0

Chemical structure

• Molecular formula: C₁₈H₁₅ClN₂O₂S
• Molecular weight: 358.84 g/mol
• CAS number: 202409-33-4
• InChIKey: MNJVRJDLRVPLFE-UHFFFAOYSA-N
• PubChem CID: 123619

CC1=NC=C(C=C1)C1=C(C=C(Cl)C=N1)C1=CC=C(C=C1)S(C)(=O)=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Etoricoxib work?

Its molecular targets in DrugCentral include PTGER2, PTGS2, MAPK14 and PTGS2 (inhibitor).

When was Etoricoxib first approved?

Etoricoxib was first approved by the YEAR INTRODUCED in 1998.

What is the chemical formula of Etoricoxib?

Etoricoxib has the molecular formula C18H15ClN2O2S and a molecular weight of 358.84 g/mol.

Sources

• DrugCentral drug card 1113 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL416146 — compound record and bioactivity
• PubChem CID 123619 — chemical identifiers
• DrugBank DB01628 — drug record
• FDA UNII WRX4NFY03R — substance identity
• UniProt P43116 (PTGER2) — target protein
• UniProt Q16539 (MAPK14) — target protein
• UniProt P35354 (PTGS2) — target protein
• UniProt P23219 (PTGS1) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.