Prostaglandin E2 receptor EP2 subtype (PTGER2)

About Prostaglandin E2 receptor EP2 subtype

Prostaglandin E2 receptor EP2 subtype (PTGER2) is a protein from Homo sapiens identified by UniProt accession P43116, 358 residues long. MolForge cross-references it against 0 known binders and 199 disease associations.

Target properties

Protein name	Prostaglandin E2 receptor EP2 subtype
UniProt accession	P43116
Gene	PTGER2
Organism	Homo sapiens
Length	358 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (199)

Diseases linked to this target (Open Targets).

erectile dysfunction · score 0.56
pregnancy · score 0.46
Premature rupture of membranes · score 0.46
myocardial infarction · score 0.46
pain · score 0.43
cardiovascular disease · score 0.38
ocular hypertension · score 0.37
open-angle glaucoma · score 0.37
stroke · score 0.37
ischemia · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P43116-F1	alphafold	PREDICTED	77.57	—

Amino-acid sequence (358 residues)

MGNASNDSQS EDCETRQWLP PGESPAISSV MFSAGVLGNL IALALLARRW RGDVGCSAGR RSSLSLFHVL VTELVFTDLL GTCLISPVVL ASYARNQTLV ALAPESRACT YFAFAMTFFS LATMLMLFAM ALERYLSIGH PYFYQRRVSR SGGLAVLPVI YAVSLLFCSL PLLDYGQYVQ YCPGTWCFIR HGRTAYLQLY ATLLLLLIVS VLACNFSVIL NLIRMHRRSR RSRCGPSLGS GRGGPGARRR GERVSMAEET DHLILLAIMT ITFAVCSLPF TIFAYMNETS SRKEKWDLQA LRFLSINSII DPWVFAILRP PVLRLMRSVL CCRISLRTQD ATQTSCSTQS DASKQADL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards