Dinoprost

GENITO URINARY SYSTEM AND SEX HORMONES

Key facts

Dinoprost is an ofm drug catalogued in DrugCentral. It was first approved by the FDA in 1976. DrugCentral lists 17 molecular targets, including PTGFR, Ptger3 and Ptgfr. Recorded indications include Cervical ripening procedure, Hydatidiform mole, benign, Incomplete miscarriage and Induction of labor.

• Approval status: ofm (first approved 1976 by the FDA).
• Molecular targets: PTGFR, Ptger3, Ptgfr and Ptger3 (17 listed in DrugCentral).
• Indications: Cervical ripening procedure, Hydatidiform mole, benign, Incomplete miscarriage, Induction of labor and Pregnancy with abortive outcome.
• ATC code: G02AD01 (Prostaglandins).
• Molecular formula: C20H34O5; molecular weight 354.49 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (5)

• Cervical ripening procedure
• Hydatidiform mole, benign
• Incomplete miscarriage
• Induction of labor
• Pregnancy with abortive outcome

Contraindications (30)

• Abnormal uterine bleeding unrelated to menstrual cycle
• Anemia
• Asthma
• Deliveries by cesarean
• Depressive disorder
• Diabetes mellitus
• Disease of liver
• Disorder of cardiovascular system
• Disorder of lung
• Disproportion between fetus and pelvis
• Disseminated intravascular coagulation
• Endocervical Lesions
• Female genital tract infection
• Fetal distress
• Genital herpes simplex
• Glaucoma
• Grand multipara
• Gynecological Surgery
• Hypertensive disorder
• Inflammation of cervix
• Kidney disease
• Low blood pressure
• Multiple pregnancy
• Ocular hypertension
• Placenta previa
• Seizure disorder
• Spontaneous rupture of membranes
• Stenosis of cervix
• Uterine Hypertonic Patterns
• Uterine leiomyoma

Mechanism & targets

Molecular targets (17)

Target	Gene	Action	Activity
Prostaglandin F2-alpha receptor	PTGFR	agonist	Kd 8.40
Prostaglandin E2 receptor EP3 subtype	Ptger3	agonist	EC50 8.38
Prostaglandin F2-alpha receptor	Ptgfr	unknown	EC50 7.90
Prostaglandin E2 receptor EP3 subtype	Ptger3	agonist	Ki 7.12
Prostaglandin E2 receptor EP3 subtype	PTGER3	unknown	IC50 6.96
Prostaglandin F2-alpha receptor	PTGFR	unknown	Ki 6.89
Prostaglandin E2 receptor EP1 subtype	PTGER1	unknown	IC50 6.66
Prostaglandin E2 receptor EP1 subtype	Ptger1	agonist	Ki 6.40
Prostaglandin D2 receptor 2	PTGDR2	agonist	Ki 6.40
Prostaglandin D2 receptor 2	Ptgdr2	agonist	Ki 6.20
Prostaglandin E2 receptor EP4 subtype	Ptger4	agonist	Ki 6.20
Prostaglandin E2 receptor EP2 subtype	PTGER2	agonist	Ki 6.00
Prostaglandin E2 receptor EP1 subtype	Ptger1	agonist	Ki 5.90
Prostaglandin E2 receptor EP2 subtype	Ptger2	agonist	Ki 5.60
Prostaglandin E2 receptor EP4 subtype	PTGER4	unknown	IC50 5.38
Prostaglandin D2 receptor	PTGDR	unknown	IC50 5.35
Thromboxane A2 receptor	TBXA2R	agonist	Ki 5.10

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1976-05-18	FDA	—	PHARMACIA AND UPJOHN

ATC classification

ATC code	Therapeutic hierarchy
G02AD01	GENITO URINARY SYSTEM AND SEX HORMONES › OTHER GYNECOLOGICALS › UTEROTONICS › Prostaglandins

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Dinoprost is on its molecule page.

• Molecular formula: C₂₀H₃₄O₅
• Molecular weight: 354.49 g/mol
• CAS number: 551-11-1
• InChIKey: PXGPLTODNUVGFL-YNNPMVKQSA-N
• PubChem CID: 5280363

CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Dinoprost used for?

DrugCentral lists the following indications for Dinoprost: Cervical ripening procedure, Hydatidiform mole, benign, Incomplete miscarriage, Induction of labor and Pregnancy with abortive outcome.

How does Dinoprost work?

Its molecular targets in DrugCentral include PTGFR (agonist), Ptger3 (agonist), Ptgfr and Ptger3 (agonist).

When was Dinoprost first approved?

Dinoprost was first approved by the FDA in 1976.

What is the chemical formula of Dinoprost?

Dinoprost has the molecular formula C20H34O5 and a molecular weight of 354.49 g/mol.

Sources

• DrugCentral drug card 912 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200896 — compound record and bioactivity
• PubChem CID 5280363 — chemical identifiers
• DrugBank DB01160 — drug record
• FDA UNII B7IN85G1HY — substance identity
• DailyMed: FDA labels for Dinoprost — current prescribing information (label search)
• UniProt P43088 (PTGFR) — target protein
• UniProt P43115 (PTGER3) — target protein
• UniProt P34995 (PTGER1) — target protein
• UniProt Q9Y5Y4 (PTGDR2) — target protein
• UniProt P43116 (PTGER2) — target protein
• UniProt P35408 (PTGER4) — target protein

How this page is built: methodology · editorial policy & corrections.