Prostaglandin E2 receptor EP1 subtype (PTGER1)

About Prostaglandin E2 receptor EP1 subtype

Prostaglandin E2 receptor EP1 subtype (PTGER1) is a protein from Homo sapiens identified by UniProt accession P34995, 402 residues long. MolForge cross-references it against 0 known binders and 298 disease associations.

Target properties

Protein name	Prostaglandin E2 receptor EP1 subtype
UniProt accession	P34995
Gene	PTGER1
Organism	Homo sapiens
Length	402 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (298)

Diseases linked to this target (Open Targets).

erectile dysfunction · score 0.56
pregnancy · score 0.46
myocardial infarction · score 0.46
Premature rupture of membranes · score 0.46
pain · score 0.43
cardiovascular disease · score 0.38
diabetic nephropathy · score 0.37
Patent ductus arteriosus · score 0.37
acute kidney failure · score 0.37
arterial occlusive disease · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P34995-F1	alphafold	PREDICTED	74.82	—

Amino-acid sequence (402 residues)

MSPCGPLNLS LAGEATTCAA PWVPNTSAVP PSGASPALPI FSMTLGAVSN LLALALLAQA AGRLRRRRSA ATFLLFVASL LATDLAGHVI PGALVLRLYT AGRAPAGGAC HFLGGCMVFF GLCPLLLGCG MAVERCVGVT RPLLHAARVS VARARLALAA VAAVALAVAL LPLARVGRYE LQYPGTWCFI GLGPPGGWRQ ALLAGLFASL GLVALLAALV CNTLSGLALL RARWRRRSRR PPPASGPDSR RRWGAHGPRS ASASSASSIA SASTFFGGSR SSGSARRARA HDVEMVGQLV GIMVVSCICW SPMLVLVALA VGGWSSTSLQ RPLFLAVRLA SWNQILDPWV YILLRQAVLR QLLRLLPPRA GAKGGPAGLG LTPSAWEASS LRSSRHSGLS HF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards