Iloprost

Prostacycline — BLOOD AND BLOOD FORMING ORGANS

Key facts

Iloprost is an ofp drug in the Prostacycline class catalogued in DrugCentral. It was first approved by the FDA in 2004. DrugCentral lists 17 molecular targets, including Ptger3, Ptgir and Ptgir. Recorded indications include Pulmonary arterial hypertension.

• Approval status: ofp (first approved 2004 by the FDA).
• Drug class: Prostacycline.
• Molecular targets: Ptger3, Ptgir, Ptgir and Ptger1 (17 listed in DrugCentral).
• Indications: Pulmonary arterial hypertension.
• ATC code: B01AC11 (Platelet aggregation inhibitors excl. heparin).
• Molecular formula: C22H32O4; molecular weight 360.49 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Pulmonary arterial hypertension

Contraindications (6)

• Bronchospasm
• Chronic obstructive lung disease
• Hepatic failure
• Low blood pressure
• Mild to Moderate Hypotension
• Pulmonary edema

Mechanism & targets

• Established pharmacologic class: Prostacycline

Molecular targets (17)

Target	Gene	Action	Activity
Prostaglandin E2 receptor EP3 subtype	Ptger3	agonist	EC50 9.20
Prostacyclin receptor	Ptgir	unknown	EC50 9.16
Prostacyclin receptor	Ptgir	agonist	Ki 8.00
Prostaglandin E2 receptor EP1 subtype	Ptger1	agonist	Ki 7.90
Prostacyclin receptor	PTGIR	agonist	EC50 7.75
Prostaglandin E2 receptor EP1 subtype	PTGER1	unknown	EC50 7.70
Prostaglandin E2 receptor EP1 subtype	Ptger1	agonist	Ki 7.70
Prostaglandin E2 receptor EP3 subtype	Ptger3	agonist	Ki 7.66
Prostaglandin E2 receptor EP3 subtype	PTGER3	unknown	EC50 7.30
Prostaglandin E2 receptor EP4 subtype	PTGER4	agonist	Ki 6.68
Prostaglandin D2 receptor	PTGDR	agonist	Ki 6.60
Prostaglandin F2-alpha receptor	PTGFR	agonist	Ki 6.20
Prostaglandin E2 receptor EP2 subtype	Ptger2	agonist	Ki 5.90
Prostaglandin E2 receptor EP2 subtype	Ptger2	agonist	Ki 5.80
Prostaglandin E2 receptor EP2 subtype	PTGER2	agonist	Ki 5.70
Prostaglandin E2 receptor EP4 subtype	Ptger4	agonist	Ki 5.60
Thromboxane A2 receptor	TBXA2R	agonist	Ki 5.20

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2004-12-29	FDA	—	ACTELION PHARMS LTD	Yes

ATC classification

ATC code	Therapeutic hierarchy
B01AC11	BLOOD AND BLOOD FORMING ORGANS › ANTITHROMBOTIC AGENTS › ANTITHROMBOTIC AGENTS › Platelet aggregation inhibitors excl. heparin

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Death	1714.7
Right ventricular failure	479.1
Dyspnoea	433.5
Fluid retention	289.0
Pulmonary hypertension	271.0
Hospitalisation	236.6
Cardiac failure	157.8
Cough	146.4
Oxygen saturation decreased	142.6
Syncope	112.4
Headache	105.0
Transfusion	102.6

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Iloprost is on its molecule page.

• Molecular formula: C₂₂H₃₂O₄
• Molecular weight: 360.49 g/mol
• CAS number: 78919-13-8
• InChIKey: HIFJCPQKFCZDDL-ACWOEMLNSA-N
• PubChem CID: 5311181

CC#CCC(C)[C@H](O)\C=C\[C@H]1[C@H](O)C[C@@H]2C\C(C[C@H]12)=C/CCCC(O)=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Iloprost used for?

DrugCentral lists the following indications for Iloprost: Pulmonary arterial hypertension.

How does Iloprost work?

Its molecular targets in DrugCentral include Ptger3 (agonist), Ptgir, Ptgir (agonist) and Ptger1 (agonist).

When was Iloprost first approved?

Iloprost was first approved by the FDA in 2004.

What drug class does Iloprost belong to?

Iloprost is in the Prostacycline class.

What is the chemical formula of Iloprost?

Iloprost has the molecular formula C22H32O4 and a molecular weight of 360.49 g/mol.

Sources

• DrugCentral drug card 1422 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL494 — compound record and bioactivity
• PubChem CID 5311181 — chemical identifiers
• DrugBank DB01088 — drug record
• FDA UNII JED5K35YGL — substance identity
• DailyMed: FDA labels for Iloprost — current prescribing information (label search)
• UniProt P43119 (PTGIR) — target protein
• UniProt P34995 (PTGER1) — target protein
• UniProt P43115 (PTGER3) — target protein
• UniProt P35408 (PTGER4) — target protein
• UniProt Q13258 (PTGDR) — target protein
• UniProt P43088 (PTGFR) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.