Prostacyclin receptor (PTGIR)

About Prostacyclin receptor

Prostacyclin receptor (PTGIR) is a protein from Homo sapiens identified by UniProt accession P43119, 386 residues long. MolForge cross-references it against 0 known binders and 130 disease associations.

Target properties

Protein name	Prostacyclin receptor
UniProt accession	P43119
Gene	PTGIR
Organism	Homo sapiens
Length	386 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (10)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (130)

Diseases linked to this target (Open Targets).

pulmonary arterial hypertension · score 0.61
pulmonary hypertension · score 0.59
Recurrent thrombophlebitis · score 0.53
neurodegenerative disease · score 0.47
cardiovascular disease · score 0.46
heart failure · score 0.46
chronic obstructive pulmonary disease · score 0.40
idiopathic pulmonary arterial hypertension · score 0.37
type 2 diabetes mellitus · score 0.37
peripheral arterial disease · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P43119-F1	alphafold	PREDICTED	76.19	—

Amino-acid sequence (386 residues)

MADSCRNLTY VRGSVGPATS TLMFVAGVVG NGLALGILSA RRPARPSAFA VLVTGLAATD LLGTSFLSPA VFVAYARNSS LLGLARGGPA LCDAFAFAMT FFGLASMLIL FAMAVERCLA LSHPYLYAQL DGPRCARLAL PAIYAFCVLF CALPLLGLGQ HQQYCPGSWC FLRMRWAQPG GAAFSLAYAG LVALLVAAIF LCNGSVTLSL CRMYRQQKRH QGSLGPRPRT GEDEVDHLIL LALMTVVMAV CSLPLTIRCF TQAVAPDSSS EMGDLLAFRF YAFNPILDPW VFILFRKAVF QRLKLWVCCL CLGPAHGDSQ TPLSQLASGR RDPRAPSAPV GKEGSCVPLS AWGEGQVEPL PPTQQSSGSA VGTSSKAEAS VACSLC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards