Prostaglandin F2-alpha receptor (PTGFR)

About Prostaglandin F2-alpha receptor

Prostaglandin F2-alpha receptor (PTGFR) is a protein from Homo sapiens identified by UniProt accession P43088, 359 residues long. MolForge cross-references it against 0 known binders and 126 disease associations.

Target properties

Protein name	Prostaglandin F2-alpha receptor
UniProt accession	P43088
Gene	PTGFR
Organism	Homo sapiens
Length	359 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (16)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (126)

Diseases linked to this target (Open Targets).

open-angle glaucoma · score 0.61
glaucoma · score 0.61
ocular hypertension · score 0.60
hypotrichosis · score 0.57
Vitiligo · score 0.53
alopecia areata · score 0.47
postpartum hemorrhage · score 0.46
low tension glaucoma · score 0.46
hypertension · score 0.46
dry eye syndrome · score 0.46

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P43088-F1	alphafold	PREDICTED	80.57	—

Amino-acid sequence (359 residues)

MSMNNSKQLV SPAAALLSNT TCQTENRLSV FFSVIFMTVG ILSNSLAIAI LMKAYQRFRQ KSKASFLLLA SGLVITDFFG HLINGAIAVF VYASDKEWIR FDQSNVLCSI FGICMVFSGL CPLLLGSVMA IERCIGVTKP IFHSTKITSK HVKMMLSGVC LFAVFIALLP ILGHRDYKIQ ASRTWCFYNT EDIKDWEDRF YLLLFSFLGL LALGVSLLCN AITGITLLRV KFKSQQHRQG RSHHLEMVIQ LLAIMCVSCI CWSPFLVTMA NIGINGNHSL ETCETTLFAL RMATWNQILD PWVYILLRKA VLKNLYKLAS QCCGVHVISL HIWELSSIKN SLKVAAISES PVAEKSAST

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards