About Thromboxane A2 receptor
Thromboxane A2 receptor (TBXA2R) is a protein
from Homo sapiens identified by UniProt accession
P21731, 343 residues long.
MolForge cross-references it against 0 known binders and
230 disease associations.
Target properties
| Protein name | Thromboxane A2 receptor |
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| UniProt accession | P21731 |
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| Gene | TBXA2R |
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| Organism | Homo sapiens |
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| Length | 343 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (9)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (230)
Diseases linked to this target (Open Targets).
- bleeding diathesis due to thromboxane synthesis deficiency · score 0.60
- neurodegenerative disease · score 0.51
- Airway obstruction · score 0.37
- Recurrent thrombophlebitis · score 0.37
- Abnormal platelet aggregation · score 0.30
- ovarian cancer · score 0.24
- neuroinflammatory disorder · score 0.20
- genetic disorder · score 0.19
- qualitative platelet defect · score 0.18
- asthma · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P21731-F1 | alphafold | PREDICTED | 86.23 | — |
Amino-acid sequence (343 residues)
MWPNGSSLGP CFRPTNITLE ERRLIASPWF AASFCVVGLA SNLLALSVLA GARQGGSHTR SSFLTFLCGL VLTDFLGLLV TGTIVVSQHA ALFEWHAVDP GCRLCRFMGV VMIFFGLSPL LLGAAMASER YLGITRPFSR PAVASQRRAW ATVGLVWAAA LALGLLPLLG VGRYTVQYPG SWCFLTLGAE SGDVAFGLLF SMLGGLSVGL SFLLNTVSVA TLCHVYHGQE AAQQRPRDSE VEMMAQLLGI MVVASVCWLP LLVFIAQTVL RNPPAMSPAG QLSRTTEKEL LIYLRVATWN QILDPWVYIL FRRAVLRRLQ PRLSTRPRSL SLQPQLTQRS GLQ
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