About Prostaglandin E2 receptor EP4 subtype
Prostaglandin E2 receptor EP4 subtype (PTGER4) is a protein
from Homo sapiens identified by UniProt accession
P35408, 488 residues long.
MolForge cross-references it against 0 known binders and
430 disease associations.
Target properties
| Protein name | Prostaglandin E2 receptor EP4 subtype |
|---|
| UniProt accession | P35408 |
|---|
| Gene | PTGER4 |
|---|
| Organism | Homo sapiens |
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| Length | 488 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Approved drugs hitting this target (15)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (430)
Diseases linked to this target (Open Targets).
- Premature rupture of membranes · score 0.46
- Crohn's disease · score 0.46
- pain · score 0.43
- serum urea measurement · score 0.40
- neurodegenerative disease · score 0.35
- inflammatory bowel disease · score 0.32
- pregnancy · score 0.32
- neuroinflammatory disorder · score 0.32
- blood urea nitrogen measurement · score 0.29
- red blood cell density measurement · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P35408-F1 | alphafold | PREDICTED | 70.88 | — |
Amino-acid sequence (488 residues)
MSTPGVNSSA SLSPDRLNSP VTIPAVMFIF GVVGNLVAIV VLCKSRKEQK ETTFYTLVCG LAVTDLLGTL LVSPVTIATY MKGQWPGGQP LCEYSTFILL FFSLSGLSII CAMSVERYLA INHAYFYSHY VDKRLAGLTL FAVYASNVLF CALPNMGLGS SRLQYPDTWC FIDWTTNVTA HAAYSYMYAG FSSFLILATV LCNVLVCGAL LRMHRQFMRR TSLGTEQHHA AAAASVASRG HPAASPALPR LSDFRRRRSF RRIAGAEIQM VILLIATSLV VLICSIPLVV RVFVNQLYQP SLEREVSKNP DLQAIRIASV NPILDPWIYI LLRKTVLSKA IEKIKCLFCR IGGSRRERSG QHCSDSQRTS SAMSGHSRSF ISRELKEISS TSQTLLPDLS LPDLSENGLG GRNLLPGVPG MGLAQEDTTS LRTLRISETS DSSQGQDSES VLLVDEAGGS GRAGPAPKGS SLQVTFPSET LNLSEKCI
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