About Prostaglandin E2 receptor EP3 subtype
Prostaglandin E2 receptor EP3 subtype (PTGER3) is a protein
from Homo sapiens identified by UniProt accession
P43115, 390 residues long.
MolForge cross-references it against 0 known binders and
314 disease associations.
Target properties
| Protein name | Prostaglandin E2 receptor EP3 subtype |
|---|
| UniProt accession | P43115 |
|---|
| Gene | PTGER3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 390 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (314)
Diseases linked to this target (Open Targets).
- hemorrhage · score 0.59
- postpartum hemorrhage · score 0.59
- osteoarthritis · score 0.58
- pregnancy · score 0.57
- Premature rupture of membranes · score 0.53
- pain · score 0.52
- abortion · score 0.47
- duodenal ulcer · score 0.46
- peptic ulcer disease · score 0.46
- spontaneous abortion · score 0.46
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P43115-F1 | alphafold | PREDICTED | 76.06 | — |
Amino-acid sequence (390 residues)
MKETRGYGGD APFCTRLNHS YTGMWAPERS AEARGNLTRP PGSGEDCGSV SVAFPITMLL TGFVGNALAM LLVSRSYRRR ESKRKKSFLL CIGWLALTDL VGQLLTTPVV IVVYLSKQRW EHIDPSGRLC TFFGLTMTVF GLSSLFIASA MAVERALAIR APHWYASHMK TRATRAVLLG VWLAVLAFAL LPVLGVGQYT VQWPGTWCFI STGRGGNGTS SSHNWGNLFF ASAFAFLGLL ALTVTFSCNL ATIKALVSRC RAKATASQSS AQWGRITTET AIQLMGIMCV LSVCWSPLLI MMLKMIFNQT SVEHCKTHTE KQKECNFFLI AVRLASLNQI LDPWVYLLLR KILLRKFCQI RYHTNNYASS STSLPCQCSS TLMWSDHLER
Explore Prostaglandin E2 receptor EP3 subtype with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets