Prostaglandin D2 receptor (PTGDR)

About Prostaglandin D2 receptor

Prostaglandin D2 receptor (PTGDR) is a protein from Homo sapiens identified by UniProt accession Q13258, 359 residues long. MolForge cross-references it against 0 known binders and 288 disease associations.

Target properties

Protein name	Prostaglandin D2 receptor
UniProt accession	Q13258
Gene	PTGDR
Organism	Homo sapiens
Length	359 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (10)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (288)

Diseases linked to this target (Open Targets).

Hypercholesterolemia · score 0.53
Disorder of lipid metabolism · score 0.48
polycystic ovary syndrome · score 0.37
coronary artery disease · score 0.37
Combined hyperlipidemia · score 0.35
hyperlipidemia · score 0.35
type 2 diabetes mellitus · score 0.27
familial hypercholesterolemia · score 0.26
eosinophil count · score 0.25
ovarian cancer · score 0.23

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q13258-F1	alphafold	PREDICTED	79.39	—

Amino-acid sequence (359 residues)

MKSPFYRCQN TTSVEKGNSA VMGGVLFSTG LLGNLLALGL LARSGLGWCS RRPLRPLPSV FYMLVCGLTV TDLLGKCLLS PVVLAAYAQN RSLRVLAPAL DNSLCQAFAF FMSFFGLSST LQLLAMALEC WLSLGHPFFY RRHITLRLGA LVAPVVSAFS LAFCALPFMG FGKFVQYCPG TWCFIQMVHE EGSLSVLGYS VLYSSLMALL VLATVLCNLG AMRNLYAMHR RLQRHPRSCT RDCAEPRADG REASPQPLEE LDHLLLLALM TVLFTMCSLP VIYRAYYGAF KDVKEKNRTS EEAEDLRALR FLSVISIVDP WIFIIFRSPV FRIFFHKIFI RPLRYRSRCS NSTNMESSL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards