Limaprost

BLOOD AND BLOOD FORMING ORGANS

Key facts

Limaprost is a drug catalogued in DrugCentral. DrugCentral lists 1 molecular target, including PTGER1. Recorded indications include Thromboangiitis obliterans.

• Molecular targets: PTGER1 (1 listed in DrugCentral).
• Indications: Thromboangiitis obliterans.
• ATC code: B01AC28 (Platelet aggregation inhibitors excl. heparin).
• Molecular formula: C22H36O5; molecular weight 380.52 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Thromboangiitis obliterans

Mechanism & targets

Molecular targets (1)

Target	Gene	Action	Activity
Prostaglandin E2 receptor EP1 subtype	PTGER1	agonist	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
—	PMDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
B01AC28	BLOOD AND BLOOD FORMING ORGANS › ANTITHROMBOTIC AGENTS › ANTITHROMBOTIC AGENTS › Platelet aggregation inhibitors excl. heparin

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Interstitial lung disease	115.9
Cardiac failure	77.8
Hepatic function abnormal	57.4
Renal impairment	55.6
Cerebral infarction	53.9
Inappropriate antidiuretic hormone secretion	50.1
Decreased appetite	46.0
Osteonecrosis of jaw	43.2
Platelet count decreased	37.8
Colitis microscopic	36.0
Altered state of consciousness	34.7
Haemorrhage subcutaneous	34.5

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Limaprost is on its molecule page.

• Molecular formula: C₂₂H₃₆O₅
• Molecular weight: 380.52 g/mol
• CAS number: —
• InChIKey: OJZYRQPMEIEQFC-UAWLTFRCSA-N
• PubChem CID: 6438378

CCCC[C@H](C)C[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCC\C=C\C(O)=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Limaprost used for?

DrugCentral lists the following indications for Limaprost: Thromboangiitis obliterans.

How does Limaprost work?

Its molecular targets in DrugCentral include PTGER1 (agonist).

What is the chemical formula of Limaprost?

Limaprost has the molecular formula C22H36O5 and a molecular weight of 380.52 g/mol.

Sources

• DrugCentral drug card 1581 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL2107456 — compound record and bioactivity
• PubChem CID 6438378 — chemical identifiers
• DrugBank DB09211 — drug record
• FDA UNII L02U804092 — substance identity
• UniProt P34995 (PTGER1) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.