Prostaglandin D2 receptor 2 (PTGDR2)
Homo sapiens — UniProt Q9Y5Y4
Data last refreshed: (UniProt release unknown)
Key facts
Prostaglandin D2 receptor 2 (PTGDR2) is a protein from Homo sapiens identified by UniProt accession Q9Y5Y4, 395 residues long. MolForge cross-references it against 7 known binders and 190 disease associations.
- UniProt accession: Q9Y5Y4; gene symbol PTGDR2.
- Organism: Homo sapiens.
- Length: 395 amino acids.
- Approved drugs acting on it (DrugCentral): Dinoprost and Dinoprostone.
- Top disease associations (Open Targets): asthma, seasonal allergic rhinitis and Nasal Cavity Polyp.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Prostaglandin D2 receptor 2 |
|---|---|
| UniProt accession | Q9Y5Y4 |
| Gene | PTGDR2 |
| Organism | Homo sapiens |
| Length | 395 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (2)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (190)
Diseases linked to this target (Open Targets).
- asthma · score 0.40
- seasonal allergic rhinitis · score 0.29
- Nasal Cavity Polyp · score 0.28
- neurodegenerative disease · score 0.19
- allergic rhinitis · score 0.11
- chronic obstructive pulmonary disease · score 0.10
- prostate adenocarcinoma · score 0.10
- atopic eczema · score 0.09
- eosinophilic esophagitis · score 0.09
- acute myeloid leukemia · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y5Y4-F1 | alphafold | PREDICTED | 80.99 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y5Y4.
Amino-acid sequence (395 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target PTGDR2?
DrugCentral lists 2 approved drugs whose mechanism of action is PTGDR2: Dinoprost and Dinoprostone.
Which diseases are associated with PTGDR2?
The strongest Open Targets associations for PTGDR2 are asthma, seasonal allergic rhinitis, Nasal Cavity Polyp, neurodegenerative disease and allergic rhinitis.
How long is the PTGDR2 protein?
The Homo sapiens PTGDR2 protein (UniProt Q9Y5Y4) is 395 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y5Y4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y5Y4 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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