Imrecoxib

Drug profile

Key facts

Imrecoxib is a drug catalogued in DrugCentral. It was first approved by the China Food and Drug Administration (CFDA) in 2011. DrugCentral lists 3 molecular targets, including PTGS2, Ptgs2 and Ptgs1. Recorded indications include Osteoarthritis.

• Molecular targets: PTGS2, Ptgs2 and Ptgs1 (3 listed in DrugCentral).
• Indications: Osteoarthritis.
• Molecular formula: C21H23NO3S; molecular weight 369.48 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Osteoarthritis

Mechanism & targets

Molecular targets (3)

Target	Gene	Action	Activity
Prostaglandin G/H synthase 2	PTGS2	inhibitor	IC50 7.82
Prostaglandin G/H synthase 2	Ptgs2	unknown	IC50 7.75
Prostaglandin G/H synthase 1	Ptgs1	unknown	IC50 6.94

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2011-05-20	China Food and Drug Administration (CFDA)	—	HengRui

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Imrecoxib is on its molecule page.

• Molecular formula: C₂₁H₂₃NO₃S
• Molecular weight: 369.48 g/mol
• CAS number: 395683-14-4
• InChIKey: AXMZZGKKZDJGAZ-UHFFFAOYSA-N
• PubChem CID: 11682175

CCCN1CC(=C(C1=O)C1=CC=C(C)C=C1)C1=CC=C(C=C1)S(C)(=O)=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Imrecoxib used for?

DrugCentral lists the following indications for Imrecoxib: Osteoarthritis.

How does Imrecoxib work?

Its molecular targets in DrugCentral include PTGS2 (inhibitor), Ptgs2 and Ptgs1.

When was Imrecoxib first approved?

Imrecoxib was first approved by the China Food and Drug Administration (CFDA) in 2011.

What is the chemical formula of Imrecoxib?

Imrecoxib has the molecular formula C21H23NO3S and a molecular weight of 369.48 g/mol.

Sources

• DrugCentral drug card 5250 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL504535 — compound record and bioactivity
• PubChem CID 11682175 — chemical identifiers
• DrugBank DB12354 — drug record
• FDA UNII SGW6W5758V — substance identity
• UniProt P35354 (PTGS2) — target protein

How this page is built: methodology · editorial policy & corrections.