Polmacoxib

MUSCULO-SKELETAL SYSTEM

Key facts

Polmacoxib is a drug catalogued in DrugCentral. It was first approved by the Korean Food and Drug Administration (KFDA) in 2015. DrugCentral lists 3 molecular targets, including Ptgs1, PTGS2 and PTGS1. Recorded indications include Osteoarthritis.

• Molecular targets: Ptgs1, PTGS2 and PTGS1 (3 listed in DrugCentral).
• Indications: Osteoarthritis.
• ATC code: M01AH07 (Coxibs).
• Molecular formula: C18H16FNO4S; molecular weight 361.39 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Osteoarthritis

Mechanism & targets

Molecular targets (3)

Target	Gene	Action	Activity
Prostaglandin G/H synthase 1	Ptgs1	unknown	IC50 8.52
Prostaglandin G/H synthase 2	PTGS2	inhibitor	IC50 8.08
Prostaglandin G/H synthase 1	PTGS1	inhibitor	IC50 6.08

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2015-02-05	Korean Food and Drug Administration (KFDA)	—	CrystalGenomics

ATC classification

ATC code	Therapeutic hierarchy
M01AH07	MUSCULO-SKELETAL SYSTEM › ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS › ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS › Coxibs

Chemical structure

• Molecular formula: C₁₈H₁₆FNO₄S
• Molecular weight: 361.39 g/mol
• CAS number: 301692-76-2
• InChIKey: IJWPAFMIFNSIGD-UHFFFAOYSA-N
• PubChem CID: 9841854

CC1(C)OC(=C(C1=O)C1=CC=CC(F)=C1)C1=CC=C(C=C1)S(N)(=O)=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Polmacoxib used for?

DrugCentral lists the following indications for Polmacoxib: Osteoarthritis.

How does Polmacoxib work?

Its molecular targets in DrugCentral include Ptgs1, PTGS2 (inhibitor) and PTGS1 (inhibitor).

When was Polmacoxib first approved?

Polmacoxib was first approved by the Korean Food and Drug Administration (KFDA) in 2015.

What is the chemical formula of Polmacoxib?

Polmacoxib has the molecular formula C18H16FNO4S and a molecular weight of 361.39 g/mol.

Sources

• DrugCentral drug card 5240 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL166863 — compound record and bioactivity
• PubChem CID 9841854 — chemical identifiers
• DrugBank DB12399 — drug record
• FDA UNII IJ34D6YPAO — substance identity
• UniProt P35354 (PTGS2) — target protein
• UniProt P23219 (PTGS1) — target protein

How this page is built: methodology · editorial policy & corrections.