About Cytochrome P450 1A2
Cytochrome P450 1A2 (CYP1A2) is a protein
from Homo sapiens identified by UniProt accession
P05177, 516 residues long.
MolForge cross-references it against 0 known binders and
380 disease associations.
Target properties
| Protein name | Cytochrome P450 1A2 |
|---|
| UniProt accession | P05177 |
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| Gene | CYP1A2 |
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| Organism | Homo sapiens |
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| Length | 516 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (380)
Diseases linked to this target (Open Targets).
- tea consumption measurement · score 0.45
- coffee consumption measurement · score 0.31
- erythrocyte count · score 0.25
- creatinine measurement · score 0.25
- creatinine clearance measurement · score 0.23
- cutaneous melanoma · score 0.23
- drug use measurement · score 0.18
- glioblastoma multiforme · score 0.18
- systolic blood pressure · score 0.16
- cardiovascular disease · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P05177-F1 | alphafold | PREDICTED | 95.56 | — |
Amino-acid sequence (516 residues)
MALSQSVPFS ATELLLASAI FCLVFWVLKG LRPRVPKGLK SPPEPWGWPL LGHVLTLGKN PHLALSRMSQ RYGDVLQIRI GSTPVLVLSR LDTIRQALVR QGDDFKGRPD LYTSTLITDG QSLTFSTDSG PVWAARRRLA QNALNTFSIA SDPASSSSCY LEEHVSKEAK ALISRLQELM AGPGHFDPYN QVVVSVANVI GAMCFGQHFP ESSDEMLSLV KNTHEFVETA SSGNPLDFFP ILRYLPNPAL QRFKAFNQRF LWFLQKTVQE HYQDFDKNSV RDITGALFKH SKKGPRASGN LIPQEKIVNL VNDIFGAGFD TVTTAISWSL MYLVTKPEIQ RKIQKELDTV IGRERRPRLS DRPQLPYLEA FILETFRHSS FLPFTIPHST TRDTTLNGFY IPKKCCVFVN QWQVNHDPEL WEDPSEFRPE RFLTADGTAI NKPLSEKMML FGMGKRRCIG EVLAKWEIFL FLAILLQQLE FSVPPGVKVD LTPIYGLTMK HARCEHVQAR LRFSIN
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