Altretamine

Alkylating Drug — ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS

Key facts

Altretamine is an ofm drug in the Alkylating Drug class catalogued in DrugCentral. It was first approved by the FDA in 1990. Its mechanism of action is classified as Alkylating Activity. DrugCentral lists 1 molecular target, including CYP1A2. Recorded indications include Malignant tumor of ovary.

• Approval status: ofm (first approved 1990 by the FDA).
• Drug class: Alkylating Drug.
• Mechanism of action: Alkylating Activity.
• Molecular targets: CYP1A2 (1 listed in DrugCentral).
• Indications: Malignant tumor of ovary.
• ATC code: L01XX03 (Other antineoplastic agents).
• Molecular formula: C9H18N6; molecular weight 210.28 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Malignant tumor of ovary

Contraindications (12)

• Anemia
• Ataxia
• Bone marrow depression
• Breastfeeding (mother)
• Leukopenia
• Mood swings
• Peripheral nerve disease
• Pregnancy, function
• Severe Bone Marrow Depression
• Thrombocytopenic disorder
• Unconscious
• Vertigo

Mechanism & targets

• Mechanism of action (MoA): Alkylating Activity
• Established pharmacologic class: Alkylating Drug

Molecular targets (1)

Target	Gene	Action	Activity
Cytochrome P450 1A2	CYP1A2	unknown	IC50 5.40

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1990-12-26	FDA	—	EISAI INC	Yes

ATC classification

ATC code	Therapeutic hierarchy
L01XX03	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS › ANTINEOPLASTIC AGENTS › OTHER ANTINEOPLASTIC AGENTS › Other antineoplastic agents

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Altretamine is on its molecule page.

• Molecular formula: C₉H₁₈N₆
• Molecular weight: 210.28 g/mol
• CAS number: —
• InChIKey: UUVWYPNAQBNQJQ-UHFFFAOYSA-N
• PubChem CID: 2123

CN(C)C1=NC(=NC(=N1)N(C)C)N(C)C

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Altretamine used for?

DrugCentral lists the following indications for Altretamine: Malignant tumor of ovary.

How does Altretamine work?

Altretamine is classified as Alkylating Activity; its molecular targets in DrugCentral include CYP1A2.

When was Altretamine first approved?

Altretamine was first approved by the FDA in 1990.

What drug class does Altretamine belong to?

Altretamine is in the Alkylating Drug class.

What is the chemical formula of Altretamine?

Altretamine has the molecular formula C9H18N6 and a molecular weight of 210.28 g/mol.

Sources

• DrugCentral drug card 141 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1455 — compound record and bioactivity
• PubChem CID 2123 — chemical identifiers
• DrugBank DB00488 — drug record
• FDA UNII Q8BIH59O7H — substance identity
• DailyMed: FDA labels for Altretamine — current prescribing information (label search)
• UniProt P05177 (CYP1A2) — target protein

How this page is built: methodology · editorial policy & corrections.