Eflornithine

Antiprotozoal — DERMATOLOGICALS

Key facts

Eflornithine is an ofp drug in the Antiprotozoal class catalogued in DrugCentral. It was first approved by the FDA in 1990. Its mechanism of action is classified as Decarboxylase Inhibitors. DrugCentral lists 3 molecular targets, including ODC1, Odc1 and Ornithine decarboxylase. Recorded indications include African trypanosomiasis, Female Facial Hirsutism and Reduce the risk of relapse for high-risk neuroblastoma (HRNB).

• Approval status: ofp (first approved 1990 by the FDA).
• Drug class: Antiprotozoal; Decarboxylase Inhibitor.
• Mechanism of action: Decarboxylase Inhibitors.
• Molecular targets: ODC1, Odc1 and Ornithine decarboxylase (3 listed in DrugCentral).
• Indications: African trypanosomiasis, Female Facial Hirsutism and Reduce the risk of relapse for high-risk neuroblastoma (HRNB).
• ATC code: D11AX16 (Other dermatologicals).
• Molecular formula: C6H12F2N2O2; molecular weight 182.17 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (3)

• African trypanosomiasis
• Female Facial Hirsutism
• Reduce the risk of relapse for high-risk neuroblastoma (HRNB)

Contraindications (2)

• Eruption of skin
• Skin irritation

Mechanism & targets

• Mechanism of action (MoA): Decarboxylase Inhibitors
• Established pharmacologic class: Antiprotozoal; Decarboxylase Inhibitor

Molecular targets (3)

Target	Gene	Action	Activity
Ornithine decarboxylase	ODC1	inhibitor	Kd 4.89
Ornithine decarboxylase	Odc1	unknown	Ki 4.41
Ornithine decarboxylase	—	inhibitor	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1990-11-28	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
D11AX16	DERMATOLOGICALS › OTHER DERMATOLOGICAL PREPARATIONS › OTHER DERMATOLOGICAL PREPARATIONS › Other dermatologicals
L01XX79	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS › ANTINEOPLASTIC AGENTS › OTHER ANTINEOPLASTIC AGENTS › Other antineoplastic agents
P01CX03	ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS › ANTIPROTOZOALS › AGENTS AGAINST LEISHMANIASIS AND TRYPANOSOMIASIS › Other agents against leishmaniasis and trypanosomiasis

Pharmacogenomics

Drug-label and guideline annotations from PharmGKB and CPIC.

• EMA label
• FDA label: MYCN · No Clinical PGx
• HCSC label

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Eflornithine is on its molecule page.

• Molecular formula: C₆H₁₂F₂N₂O₂
• Molecular weight: 182.17 g/mol
• CAS number: 70052-12-9
• InChIKey: VLCYCQAOQCDTCN-UHFFFAOYSA-N
• PubChem CID: 3009

NCCCC(N)(C(F)F)C(O)=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Eflornithine used for?

DrugCentral lists the following indications for Eflornithine: African trypanosomiasis, Female Facial Hirsutism and Reduce the risk of relapse for high-risk neuroblastoma (HRNB).

How does Eflornithine work?

Eflornithine is classified as Decarboxylase Inhibitors; its molecular targets in DrugCentral include ODC1 (inhibitor), Odc1 and Ornithine decarboxylase (inhibitor).

When was Eflornithine first approved?

Eflornithine was first approved by the FDA in 1990.

What drug class does Eflornithine belong to?

Eflornithine is in the Antiprotozoal class.

What is the chemical formula of Eflornithine?

Eflornithine has the molecular formula C6H12F2N2O2 and a molecular weight of 182.17 g/mol.

Sources

• DrugCentral drug card 990 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1201037 — compound record and bioactivity
• PubChem CID 3009 — chemical identifiers
• DrugBank DB06243 — drug record
• FDA UNII ZQN1G5V6SR — substance identity
• DailyMed: FDA labels for Eflornithine — current prescribing information (label search)
• UniProt P11926 (ODC1) — target protein
• PharmGKB / CPIC — pharmacogenomic label annotations

How this page is built: methodology · editorial policy & corrections.