Ornithine decarboxylase (ODC1)

About Ornithine decarboxylase

Ornithine decarboxylase (ODC1) is a protein from Homo sapiens identified by UniProt accession P11926, 461 residues long. MolForge cross-references it against 0 known binders and 328 disease associations.

Target properties

Protein name	Ornithine decarboxylase
UniProt accession	P11926
Gene	ODC1
Organism	Homo sapiens
Length	461 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (328)

Diseases linked to this target (Open Targets).

neurodevelopmental disorder with alopecia and brain abnormalities · score 0.63
Global developmental delay · score 0.46
Intellectual disability · score 0.46
Alopecia · score 0.46
alopecia · score 0.46
Macrocephaly · score 0.46
ectodermal dysplasia syndrome · score 0.46
Neurodevelopmental disorder · score 0.38
Familial adenomatous polyposis · score 0.36
trypanosomiasis · score 0.36

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P11926-F1	alphafold	PREDICTED	88.02	—

Amino-acid sequence (461 residues)

MNNFGNEEFD CHFLDEGFTA KDILDQKINE VSSSDDKDAF YVADLGDILK KHLRWLKALP RVTPFYAVKC NDSKAIVKTL AATGTGFDCA SKTEIQLVQS LGVPPERIIY ANPCKQVSQI KYAANNGVQM MTFDSEVELM KVARAHPKAK LVLRIATDDS KAVCRLSVKF GATLRTSRLL LERAKELNID VVGVSFHVGS GCTDPETFVQ AISDARCVFD MGAEVGFSMY LLDIGGGFPG SEDVKLKFEE ITGVINPALD KYFPSDSGVR IIAEPGRYYV ASAFTLAVNI IAKKIVLKEQ TGSDDEDESS EQTFMYYVND GVYGSFNCIL YDHAHVKPLL QKRPKPDEKY YSSSIWGPTC DGLDRIVERC DLPEMHVGDW MLFENMGAYT VAAASTFNGF QRPTIYYVMS GPAWQLMQQF QNPDFPPEVE EQDASTLPVS CAWESGMKRH RAACASASIN V

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards