About Thromboxane-A synthase
Thromboxane-A synthase (TBXAS1) is a protein
from Homo sapiens identified by UniProt accession
P24557, 533 residues long.
MolForge cross-references it against 0 known binders and
181 disease associations.
Target properties
| Protein name | Thromboxane-A synthase |
|---|
| UniProt accession | P24557 |
|---|
| Gene | TBXAS1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 533 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (181)
Diseases linked to this target (Open Targets).
- ghosal hematodiaphyseal dysplasia · score 0.80
- platelet-type bleeding disorder 14 · score 0.55
- cerebral infarction · score 0.38
- Recurrent thrombophlebitis · score 0.37
- bone disease · score 0.37
- anemia (phenotype) · score 0.37
- dry eye syndrome · score 0.36
- body height · score 0.32
- protein measurement · score 0.30
- systolic blood pressure · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P24557-F1 | alphafold | PREDICTED | 91.34 | — |
Amino-acid sequence (533 residues)
MEALGFLKLE VNGPMVTVAL SVALLALLKW YSTSAFSRLE KLGLRHPKPS PFIGNLTFFR QGFWESQMEL RKLYGPLCGY YLGRRMFIVI SEPDMIKQVL VENFSNFTNR MASGLEFKSV ADSVLFLRDK RWEEVRGALM SAFSPEKLNE MVPLISQACD LLLAHLKRYA ESGDAFDIQR CYCNYTTDVV ASVAFGTPVD SWQAPEDPFV KHCKRFFEFC IPRPILVLLL SFPSIMVPLA RILPNKNRDE LNGFFNKLIR NVIALRDQQA AEERRRDFLQ MVLDARHSAS PMGVQDFDIV RDVFSSTGCK PNPSRQHQPS PMARPLTVDE IVGQAFIFLI AGYEIITNTL SFATYLLATN PDCQEKLLRE VDVFKEKHMA PEFCSLEEGL PYLDMVIAET LRMYPPAFRF TREAAQDCEV LGQRIPAGAV LEMAVGALHH DPEHWPSPET FNPERFTAEA RQQHRPFTYL PFGAGPRSCL GVRLGLLEVK LTLLHVLHKF RFQACPETQV PLQLESKSAL GPKNGVYIKI VSR
Explore Thromboxane-A synthase with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets