About Adenosine receptor A2a
Adenosine receptor A2a (ADORA2A) is a protein
from Homo sapiens identified by UniProt accession
P29274, 412 residues long.
MolForge cross-references it against 0 known binders and
632 disease associations.
Target properties
| Protein name | Adenosine receptor A2a |
|---|
| UniProt accession | P29274 |
|---|
| Gene | ADORA2A |
|---|
| Organism | Homo sapiens |
|---|
| Length | 412 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (632)
Diseases linked to this target (Open Targets).
- migraine disorder · score 0.61
- asthma · score 0.60
- paroxysmal tachycardia · score 0.59
- Apnea · score 0.58
- pain · score 0.58
- Parkinson disease · score 0.57
- Wolff-Parkinson-White Syndrome · score 0.57
- Airway obstruction · score 0.57
- chronic obstructive pulmonary disease · score 0.55
- Headache · score 0.55
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P29274-F1 | alphafold | PREDICTED | 80.37 | — |
Amino-acid sequence (412 residues)
MPIMGSSVYI TVELAIAVLA ILGNVLVCWA VWLNSNLQNV TNYFVVSLAA ADIAVGVLAI PFAITISTGF CAACHGCLFI ACFVLVLTQS SIFSLLAIAI DRYIAIRIPL RYNGLVTGTR AKGIIAICWV LSFAIGLTPM LGWNNCGQPK EGKNHSQGCG EGQVACLFED VVPMNYMVYF NFFACVLVPL LLMLGVYLRI FLAARRQLKQ MESQPLPGER ARSTLQKEVH AAKSLAIIVG LFALCWLPLH IINCFTFFCP DCSHAPLWLM YLAIVLSHTN SVVNPFIYAY RIREFRQTFR KIIRSHVLRQ QEPFKAAGTS ARVLAAHGSD GEQVSLRLNG HPPGVWANGS APHPERRPNG YALGLVSGGS AQESQGNTGL PDVELLSHEL KGVCPEPPGL DDPLAQDGAG VS
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