Phenolphthalein

ALIMENTARY TRACT AND METABOLISM

Key facts

Phenolphthalein is a drug catalogued in DrugCentral. DrugCentral lists 6 molecular targets, including TYMS, thyA and ESR1.

• Molecular targets: TYMS, thyA, ESR1 and thyA (6 listed in DrugCentral).
• ATC code: A06AB04 (Contact laxatives).
• Molecular formula: C20H14O4; molecular weight 318.33 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Off-label uses (2)

• Constipation
• Incomplete passage of stool

Contraindications (3)

• Appendicitis
• Gastrointestinal obstruction
• Incontinence of feces

Mechanism & targets

Molecular targets (6)

Target	Gene	Action	Activity
Thymidylate synthase	TYMS	unknown	Ki 5.92
Thymidylate synthase	thyA	unknown	Ki 5.85
Estrogen receptor	ESR1	unknown	IC50 5.43
Thymidylate synthase	thyA	unknown	Ki 5.33
Thymidylate synthase	thyA	unknown	Ki 5.33
Estrogen receptor beta	ESR2	unknown	IC50 4.85

ATC classification

ATC code	Therapeutic hierarchy
A06AB04	ALIMENTARY TRACT AND METABOLISM › DRUGS FOR CONSTIPATION › DRUGS FOR CONSTIPATION › Contact laxatives

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Sedation complication	292.4
Creatinine renal clearance decreased	285.7
Blood calcium decreased	244.8
Renal function test abnormal	232.2
Creatinine renal clearance increased	224.8
Orthostatic hypotension	209.8
Sedation	204.2

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Phenolphthalein is on its molecule page.

• Molecular formula: C₂₀H₁₄O₄
• Molecular weight: 318.33 g/mol
• CAS number: 77-09-8
• InChIKey: KJFMBFZCATUALV-UHFFFAOYSA-N
• PubChem CID: 4764

OC1=CC=C(C=C1)C1(OC(=O)C2=C1C=CC=C2)C1=CC=C(O)C=C1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Phenolphthalein work?

Its molecular targets in DrugCentral include TYMS, thyA, ESR1 and thyA.

What is the chemical formula of Phenolphthalein?

Phenolphthalein has the molecular formula C20H14O4 and a molecular weight of 318.33 g/mol.

Sources

• DrugCentral drug card 2135 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL63857 — compound record and bioactivity
• PubChem CID 4764 — chemical identifiers
• DrugBank DB04824 — drug record
• FDA UNII 6QK969R2IF — substance identity
• UniProt P04818 (TYMS) — target protein
• UniProt P03372 (ESR1) — target protein
• UniProt Q92731 (ESR2) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.