Thymidylate synthase (TYMS)

About Thymidylate synthase

Thymidylate synthase (TYMS) is a protein from Homo sapiens identified by UniProt accession P04818, 313 residues long. MolForge cross-references it against 0 known binders and 552 disease associations.

Target properties

Protein name	Thymidylate synthase
UniProt accession	P04818
Gene	TYMS
Organism	Homo sapiens
Length	313 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (12)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (552)

Diseases linked to this target (Open Targets).

non-small cell lung carcinoma · score 0.63
neoplasm · score 0.61
breast cancer · score 0.61
colorectal cancer · score 0.60
dyskeratosis congenita · score 0.60
metastatic colorectal cancer · score 0.59
breast carcinoma · score 0.58
colonic neoplasm · score 0.58
breast neoplasm · score 0.57
actinic keratosis · score 0.57

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P04818-F1	alphafold	PREDICTED	93.80	—

Amino-acid sequence (313 residues)

MPVAGSELPR RPLPPAAQER DAEPRPPHGE LQYLGQIQHI LRCGVRKDDR TGTGTLSVFG MQARYSLRDE FPLLTTKRVF WKGVLEELLW FIKGSTNAKE LSSKGVKIWD ANGSRDFLDS LGFSTREEGD LGPVYGFQWR HFGAEYRDME SDYSGQGVDQ LQRVIDTIKT NPDDRRIIMC AWNPRDLPLM ALPPCHALCQ FYVVNSELSC QLYQRSGDMG LGVPFNIASY ALLTYMIAHI TGLKPGDFIH TLGDAHIYLN HIEPLKIQLQ REPRPFPKLR ILRKVEKIDD FKAEDFQIEG YNPHPTIKME MAV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards